重组人嗅素蛋白4(嗅觉介导素4)(OLFM4)(Olfact

特别提示：包括重组人嗅素蛋白4(嗅觉介导素4)(OLFM4)(Olfactomedin4)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人嗅素蛋白4(嗅觉介导素4)(OLFM4)(Olfactomedin4)
英文名称：Recombinant Human Olfactomedin-4
产品货号：JN1613
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Asp21-Gln510在C端带His标签。

OLFM4质量控制：＞95%(还原性SDS-PAGE)

OLFM4制剂：冻干品

OLFM4保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

OLFM4复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于OLFM4：
Olfactomedin-4/OLFM4 is a secreted protein which contains one olfactomedin-like domain. OLFM4 is expressed during myeloid lineage development,it strongly expressed in the prostate,small intestine,colon and moderately expressed in the bone marrow and stomach.OLFM4 is an antiapoptotic factor that promotes tumor growth. It expressed at high levels in stomach cancer and colon cancer tissues. it promotes proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase.In myeloid leukemic cell lines, OLFM4 inhibits cell growth and induces cell differentiation and apoptosis. Through interaction with cell surface lectins and cadherin, OLFM4 facilitates cell adhesion. It may play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation.Induction of OLFM4 in cancer cells was reported to have a novel antiapoptotic action via binding to the potent apoptosis inducer GRIM-19.

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