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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
680622-70-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1760.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥540.0 |
| 规格： | 5 mg | 产品价格： | ￥1600.0 |
| 规格： | 10 mg | 产品价格： | ￥3000.0 |
| 规格： | 25 mg | 产品价格： | ￥4300.0 |
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PIN1 inhibitor API-1
CAS No. : 680622-70-2
MCE 国际站：PIN1 inhibitor API-1
产品活性：PIN1 inhibitor API-1 是一种特殊的 Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) 抑制剂 (API-1)，IC50 为 72.3 nM。PIN1 inhibitor API-1 直接特异性地与 Pin1 肽基脯氨酰异构酶 (PPIase) 结构域结合，并抑制 Pin1 顺反异构活性。PIN1 inhibitor API-1 保留 pXPO5 的活性构象，恢复 pXPO5 将前 miRNA 从细胞核转运到细胞质的能力，从而上调抗癌 miRNA 的生物发生，抑制体外和体内肝癌的发生。
研究领域：Epigenetics
作用靶点：MicroRNA
In Vitro: PIN1 inhibitor API-1 obviously inhibits SK-Hep-1, SNU-423, and Hep3B cell proliferation with low IC50 values (IC50=0.683-4.16 μM).
In Vivo: PIN1 inhibitor API-1 suppresses tumor growth in mice by up-regulating mature miRNA biogenesis.
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文献和实验[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
apoptosis inhibitor 5 (API5), mRNA 1173 NM_006401 Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member B (ANP32B), mRNA 2354 NM_006423 Homo sapiens Rab acceptor 1 (prenylated) (RABAC1), mRNA 1706 NM_006460 Homo sapiens HMBA
are sequenced, since the third resulted from elution with a nonselective inhibitor.Once one has identified an eluted protein, one has all the necessary information on how to proceed. The first decision is biological relevance. Does the eluted protein(s
所有的看家基因(housekeeping genes)的列表+引物设计服务
tubulin, gamma complex associated protein 2 (TUBGCP2), mRNA 701 NM_006595 Homo sapiens apoptosis inhibitor 5 (API5), mRNA 1173 NM_006401 Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
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