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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1706524-94-8
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1229.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥613.0 |
| 规格： | 5 mg | 产品价格： | ￥1350.0 |
| 规格： | 10 mg | 产品价格： | ￥2300.0 |
| 规格： | 25 mg | 产品价格： | ￥5000.0 |
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ML-00253764 hydrochloride
CAS No. : 1706524-94-8
MCE 国际站：ML-00253764 hydrochloride
产品活性：ML-00253764 是一种非肽类黑皮质素受体 4 (MC4R) 拮抗剂，其 Ki 和 IC50 值分别为 0.16 µM 和 0.103 µM。脑渗透剂。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Melanocortin Receptor
In Vitro: ML-00253764 displaces NDP-α-MSH binding with a mean IC50 of 0.32 μM, 0.81 μM and 2.12 μM for hMC4-R, hMC3-R and hMC5-R, respectively.
ML-00253764 (100 µM) decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH) by 20% in MC4R-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing membranes.
In Vivo: ML-00253764 (subcutaneous injection; 3, 10, or 30 mg/kg; once daily) shows protection against tumor-induced body weight loss upon chronic, peripheral dosing in CT-26 tumor bearing BALB/c mice.
ML-00253764 dissolves in polyethylene glycol 200/saline (1:10) in a volume of 10 mL/kg (For reference only).
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文献和实验，1000，2000 bp 片段，以 pBS 质粒为模板扩增 1500 bp 片段。 模板：pUC19 质粒 30 ng/50 μL or pBS 质粒 30 ng/50 μL PCR 扩增程序： 循环数 Step 温度 时间 1 1 94 ℃ 2 min 35 1 94 ℃ 45 sec 2 55 ℃ 45 sec 3 72 ℃ 2 min 1 1 72 ℃ 5 min 2．质粒菌液直接扩增： 以 pUC19 菌液为模板扩增 100，250，500，750，1000
Single Primer ("Semi-Random") P
to about 1 ng/µL 3 µL "T/TS" @ 0.4 u Taq/µL -------- 30 µL Cycle as follows: 30"x94°C 20 cycles 0"x94°C 0"x55°C 1'x72° S=9 30 cycles 0"x94°C 0"x40°C 1'x72° S=6 30 cycles 0"x94°C 0"x55°C 1'x72° S=9 Clean up: Add 1 µL ExoI
onto the top of the mineral oil overlay. Set sample in ice bucket until all samples have been prepared. Microfuge briefly to move the master mix through the mineral oil overlay. Rapidly heat the samples to 94°C and cycle 30 times through a program appropriate
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