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- MedChemExpress(MCE)
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- HY-108263
- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CGP52421
- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- 规格：
1 mg
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3-Hydroxy Midostaurin
CAS No. : 179237-49-1
MCE 国际站：3-Hydroxy Midostaurin
产品活性：3-Hydroxy Midostaurin (CGP 52421) 是 PKC412 的代谢产物，可有效抑制 FMS 样酪氨酸激酶 3 (FLT3) 自磷酸化，在培养基和血浆中的 IC50 分别为 132 nM 和 9.8 μM。与 PKC412 相比，3-Hydroxy Midostaurin 的选择性较低，但细胞毒性更高。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：FLT3
In Vitro: CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM.
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