Gisadenafil吉沙那非,334826-98-1

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Gisadenafil

CAS No. : 334826-98-1

MCE 国际站：Gisadenafil

产品活性：Gisadenafil (UK-369003) 是一种特异性的，口服活性的磷酸二酯酶 5 (PDE5) 抑制剂，IC₅₀ 为 3.6 nM，可防止环状鸟苷单磷酸 (cGMP) 降解。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphodiesterase (PDE)

In Vitro: Since some PDE5 inhibitors can also interact with PDE1 isotypes found within the cerebral vasculature, the specificity of Gisadenafil for PDE5 is confirmed. This is directly tested with recombinant PDE5A and PDE1A overexpressed in COS-7 cells. The IC₅₀ of Gisadenafil for PDE5A is 3.6 nM. In contrast, the IC₅₀ of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in specificity.

In Vivo: Gisadenafil (2 mg/kg; intraperitoneal injection; for 2 hours; male Tat-transgenic mice) treatment largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline). Gisadenafil also restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels.

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