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- 2025年12月05日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥491.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥446.0 |
| 规格： | 10 mg | 产品价格： | ￥715.0 |
| 规格： | 25 mg | 产品价格： | ￥1548.0 |
| 规格： | 50 mg | 产品价格： | ￥2320.0 |
| 规格： | 100 mg | 产品价格： | ￥3520.0 |
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BAY-678
CAS No. : 675103-36-3
MCE 国际站：BAY-678
产品活性：BAY-678 是具有口服生物活性的、高效的、选择性的、人中性粒细胞弹性蛋白酶 (HNE) 的细胞渗透性抑制剂，其 IC50 值为 20 nM。BAY-678 也是被基因结构组学联盟 (SGC) 推荐的化学探针。
研究领域：Metabolic Enzyme/Protease
作用靶点：Elastase
In Vitro: BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. The Ki value of BAY-678 for MNE is 700 nM. BAY-678 is the 4th generation inhibitor of HNE. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). BAY-678 has more than 2,000-fold selectivity in a panel of 21 serine proteases.
In Vivo: BAY-678 (17) reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating their anti-inflammatory and anti-remodeling mode of action. Additionally, BAY-678 (17) has shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.
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