RORγt Inverse agonist 6,188716

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RORγt Inverse agonist 6

CAS No. : 1887161-80-9

MCE 国际站：RORγt Inverse agonist 6

产品活性：RORγt Inverse agonist 6 (compound 43) 是 RORγt 的反向激动剂，可用于 Th17 驱动的自身免疫性疾病的研究。RORγt Inverse agonist 6 (compound 43) 通过刺激IL-23 来抑制IL-17A的表达。

研究领域：Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor

作用靶点：ROR

In Vivo: RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model.
RORγt Inverse agonist 6 (compound 43) exhibits improved drug exposure (mouse AUC: 1289 ng•h/mL at 1 mg/kg, po).
RORγt Inverse agonist 6 (compound 43, 30 mg/kg, po, b.i.d) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose.

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