滋养层细胞抗原3β-HSD抗体

产品货号 :  jlcR16551
英文名称 :  HSD3B1+ HSD3B2
中文名称 : 滋养层细胞抗原3β-HSD抗体
别    名 :  3 beta and steroid delta isomerase 1; 3 beta and steroid hydroxy delta 5 steroid dehydrogenase; 3 beta HSD I; 3BH; 3BHSD; HGNC:5217; HSD3B; HSD3B1; HSDB3; HSDB3A; Hydroxy delta 5 steroid dehydrogenase 3 beta and steroid delta isomerase 1; Hydroxy delta 5 steroid dehydrogenase; trophoblast antigen; 3BHS1_HUMAN; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; Short=3-beta-HSD I; Trophoblast antigen FDO161G; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta-5-3-ketosteroid isomerase.   
研究领域 :  肿瘤  细胞生物  免疫学  
抗体来源 :  Rabbit
克隆类型 :  Polyclonal
交叉反应  :  Human, Mouse, Rat, Dog, Horse,
产品应用 :  WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 :  41kDa
细胞定位 :  细胞浆 细胞膜
性    状 :  Lyophilized or Liquid
浓    度 :  1mg/1ml
免 疫 原 :  KLH conjugated synthetic peptide derived from human HSD3B1+ HSD3B2:101-200/372
亚    型 :  IgG
纯化方法 :  affinity purified by Protein A
储 存 液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :  PubMed
产品介绍 :   The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Tissue Specificity:
Placenta and skin. Predominantly expressed in mammary gland tissue.

Similarity:
Belongs to the 3-beta-HSD family.

SWISS:
P14060

Gene ID:
3283

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HSD3B1属于滋养层细胞标记物（也包括hPL、hCG、Mel-CAN、p63、HLA—G、CK18和inhibin-α） 在很多肿瘤及正常内分泌组织中表达也很高

产品图片