- ¥1580 - 2480
- gelatins
- jlcR12113
- 国内
- 2025年07月12日
- WB,ELISA等
- 人/动物/植物
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
105
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
CHRNA9
- 抗体名：
yan碱型乙酰胆碱受体α9/AChRα9抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul/200ul
| 规格： | 100ul | 产品价格： | ¥1580.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ¥2480.0 |
英文名称 : CHRNA9
中文名称 : yan碱型乙酰胆碱受体α9/AChRα9抗体
别 名 : Cholinergic receptor nicotinic alpha 9; Cholinergic receptor nicotinic alpha polypeptide 9; HSA243342; MGC142109; MGC142135; NACHR alpha 9; NACHRA9; Neuronal acetylcholine receptor protein subunit alpha 9 precursor; ACHA9_HUMAN.
研究领域 : 神经生物学 通道蛋白 细胞膜受体 淋巴细胞 t-淋巴细胞 b-淋巴细胞
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 52kDa
细胞定位 : 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human CHRNA9:51-150/479 <Extracellular>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. AChR alpha 9 is the only AChR found in cochlear hair cells. In adult rat cochlear outer hair cells (OHCs), AChR alpha 9 is expressed primarily in basal regions, where it is a component of the cholinergic receptor, while in inner hair cells (IHCs), it is expressed primarily in apical regions. The alpha 9 subunit mediates efferent synaptic transmission between cholinergic olivocochlear fibers and OHCs. One of the main functions of the AChR alpha 9 channel is to provide a pathway for calcium ion influx. AChR alpha 9 may also influence the arrival of efferent axons.
Function:
CHRNA9 is a member of the ligand gated ionic channel family and nicotinic acetylcholine receptor superfamily. CHRNA9 forms homo- or hetero-oligomeric divalent cation channels. It is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. The protein is additionally expressed in keratinocytes, the pituitary gland, B-cells and T-cells.
Subunit:
Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.
Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable). Cell membrane; Multi-pass membrane protein (Probable).
Tissue Specificity:
Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.
Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-9/CHRNA9 sub-subfamily.
SWISS:
Q9UGM1
Gene ID:
55584
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验（AchR）抗体可结合到横纹肌细胞的乙酰胆碱受体上，引起运动终板的破坏，使神经-肌肉之间的信号传导发生障碍，导致骨髓肌运动无力，称为重症肌无力（myastherniagravis，MG）。疾病可发于任何年龄，最先出现的症状常是眼肌无力，进而累及其他部位，常呈进行性加重。 抗AchR抗体多用较敏感的方法进行检测。①ELISA法：以α-银环蛇毒素包被酶标板，并与骨骼肌匀浆（含AchR）作用，再加入待测血清和对照血清，最后加酶标抗体。试验的正常结果为阴性或≤0.03mmol/L.②放免法：将放射
，Bartels等合成了称之为Bis-Q(trans-3,3`-bis[(α-trimethyl ammonio methyl)azobenzene]的化合物，发现Bis-Q可模拟乙酰胆硷（acetylcholine,Ach）与乙酰胆硷受体（acetylcholine receptor,AchR）结合。继而，Erlanger将Bis-Q与蛋白 载体 交联，制备了Bis-Q特异性抗体。1982年Wassermann等用抗Bis-Q抗体免疫家兔，由于抗Bis-Q能模拟AchR，免疫后产生
，使受体活化并促进甲状腺素的释放；过多的甲状腺素引起机体的代谢亢进。 （二）抗乙酰胆碱受体抗体 抗乙酰胆碱受体（AchR）抗体可结合到横纹肌细胞的乙酰胆碱受体上，引起运动终板的破坏，使神经－肌肉之间的信号传导发生障碍，导致骨髓肌运动无力医学|教育网搜集整理，称为重症肌无力（myastherniagravis，MG）。疾病可发于任何年龄，最先出现的症状常是眼肌无力，进而累及其他部位，常呈进行性加重。 抗AchR抗体多用较敏感的方法进行检测。①ELISA法：以α-银环蛇毒素包被
技术资料暂无技术资料 索取技术资料
