Anti-NOD1 antibody

Anti-NOD1 antibody

Cat. No.     JC261512
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-NOD1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human NOD1
Reactivity                 Human, Mouse
Content                     0.8 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 NOD1
Full name                 nucleotide-binding oligomerization domain containing 1
Synonyms    CARD4; NLRC1; CLR7.1
Swissprot    Q9Y239

Target Background
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 50-200    Predicted cell location: Cytoplasm
Positive control: Human colon cancer
Recommended dilution: 50-200
            
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml261512(NOD1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)    The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using ml261512(NOD1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

ELISA
Recommended dilution: 1000-5000