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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
98
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
HEBP1
- 抗体名：
血红素结合蛋白1抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul/200ul
| 规格： | 100ul | 产品价格： | ¥1580.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ¥2480.0 |
英文名称 : HEBP1
中文名称 : 血红素结合蛋白1抗体
别 名 : HBP; HEBP; Hebp1; HEBP1_HUMAN; Heme binding protein 1; Heme-binding protein 1; p22HBP. 研究领域 : 心血管 信号转导 结合蛋白
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 21kDa
细胞定位 : 细胞浆
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human HEBP1/p22HBP:51-150/189
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : p22HBP, also known as HEBP1 (heme binding protein 1), HBP or HEBP, is a 189 amino acid intracellular tetrapyrrole-binding protein that assists in prevention of cellular toxicity by removing free porphyrinogens from the cell. Existing as a monomer, p22HBP localizes to cytoplasm and contains a 21 amino acid chemoattractant within its N-terminus that functions as a natural ligand for FPR3. p22HBP is a member of the HEBP family and binds N-methylprotoporphyrin and metalloporphyrins with similar affinity to porphyrinogens. The gene encoding p22HBP maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.
Function:
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.
Subunit:
Monomer.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.
Similarity:
Belongs to the HEBP family.
SWISS:
Q9NRV9
Gene ID:
50865
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
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文献和实验血红素结合蛋白（hemopexin,Hpx）分子量5.7万，单链多肽，含糖量约22%。正常血浆中含量为500-1000μg/L，和游离血红素有特异结合能力。它可配合结合珠蛋白对血红蛋白进行处理。当广泛溶血时，血浆结合珠蛋白耗竭，循环中游离的血红蛋白可降解为珠蛋白和血红素两部分。血红素不溶于水，可与Hpx结合成复合物而运输到肝，分子中的铁可被机体重新利用，卟啉环降解为胆红素而由胆管排出。Hpx并不能与血红蛋白结合，仅可与血红素可逆地结合，而在血循环中反复利用，这是机体有效地保
抗肝肾微粒体抗体（LKM）是一种自身抗体。是诊断II型自身免疫性肝炎的血清学指标，靶抗原为LKM-1(细胞色素P450IID6)、LKM-2、LKM-3和肝微粒体。 自身免疫性肝炎按血清学标志至少可分为三型：Ⅰ型（“狼疮样”肝炎）以出现抗核抗体(ANA)、平滑肌抗体(ASMA)、肝细胞膜抗体(LMA抗体)为特征；Ⅱ型以出现LKM抗体为特征；Ⅲ型以出现可溶性肝抗原抗体(SLA抗体)为特征。 LKM-1抗体为自身免疫性肝炎Ⅱ型的血清
相关专题 凝胶迁移或电泳迁移率实验原理 凝胶迁移或电泳迁移率实验(EMSA-electrophoretic mobility shift assay)是一种研究DNA结合蛋白和其相关的DNA结合序列相互作用的技术，可用于定性和定量分析。这一技术最初用于研究DNA结合蛋白，目前已用于研究RNA结合蛋白和特定的RNA序列的相互作用。 具体实验操作中，我们通常将纯化的蛋白和细胞粗提液和32
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