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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
44
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
phospho-MRCL3 (Thr18 + Ser19)
- 抗体名：
磷酸化肌球蛋白调节轻链MRLC3抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul/200ul
| 规格： | 100ul | 产品价格： | ¥1580.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ¥2480.0 |
英文名称 : phospho-MRCL3 (Thr18 + Ser19)
中文名称 : 磷酸化肌球蛋白调节轻链MRLC3抗体
别 名 : MRCL3 (phospho T18 + S19); ML12A_HUMAN; MLC 2B; MLC-2B; MLCB; MYL12A; Myosin regulatory light chain 12A; Myosin regulatory light chain 2; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRCL3; Myosin regulatory light chain MRLC3; Myosin RLC; Myosin, light polypeptide, regulatory, non sarcomeric (20kD); nonsarcomeric; RLC. 研究领域 : 肿瘤 心血管 细胞生物 信号转导 细胞骨架
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Sheep,
产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 20kDa
细胞定位 : 细胞浆
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthesised phosphopeptide derived from human MRCL3 around the phosphorylation site of Thr18 + Ser19:RA(p-T)(p-S)N
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Myosin is a highly conserved, ubiquitously expressed protein that interacts with Actin to generate the force for cellular movements. Conventional myosins are hexameric proteins consisting of two heavy chain subunits, a pair of non-phosphorylatable light chain subunits and a pair of phosphorylatable light chain subunits. Three general classes of myosin have been cloned: smooth muscle myosins, striated muscle myosins and non-muscle myosins. Myosin regulatory light chains, including MRCL3 (also known as MRLC3 or MLCB), MRLC2 (also known as MLC-B) and MYL9 (also known as LC20, MLC2, MRLC1 or MYRL2), regulate contraction in smooth muscle and non-muscle cells via phosphorylation by myosin light chain kinase (MLCK). Phosphorylation of myosin regulatory light chains, catalyzed by MLCK in the presence of calcium and calmodulin, increases the Actin-activated myosin ATPase activity, thereby regulating the contractile activity. Myosin light chain is also located in striated skeletal muscle, where its function remains undefined.
Function:
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.
Post-translational modifications:
Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge.
Similarity:
Contains 3 EF-hand domains.
SWISS:
P19105
Gene ID:
10627
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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文献和实验举世闻名的「伟哥」，可能存在致命副作用？JAHA：促进这种疾病恶化，相关人群需谨慎使用
探讨了西地那非对实验性小鼠腹主动脉瘤（Abdominal Aortic Aneurysm, AAA）的影响，研究结果表明，西地那非可通过调节 SMC 收缩功能而加重了主动脉退变和腹主动脉瘤的进展。 图片来源：JAHA 研究背景 SMC 收缩主要依赖于肌球蛋白轻链（MLC）的磷酸化状态，受肌球蛋白轻链激酶（MLCK）和肌球蛋白轻链磷酸酶（MLCP）活性的调节。MLCK 激活导致平滑肌收缩，主要依赖于 Ca2+ 和钙调素的水平；相反，MLCP 的激活会导致平滑肌松弛。 cGMP 可以通过多
有关。 TCR-pMHC信号转导通过T细胞骨架蛋白重排诱导免疫突触形成 首先涉及左下方的肌动蛋白多聚化调节分子RhoA，这是TCR识别MHC提呈的抗原肽后，借助蛋白酪氨酸激酶Fyn和Lck等激活ZAP-70，后者且通过IrAT招募SLP-76和NCK等一系列衔接蛋白，使鸟苷酸置换因子Vavl磷酸化后所激活的主要分子。二是LFA-1分子胞内段可结合一种连接质膜与细胞骨架的踝蛋白(Talin)的分子，共同参与肌动蛋白构型的变更。另外微管组织中心(MTOS)对微管装配的调节，也可改变胞内的细胞
轻链组成，并组成三个结构和功能不同的结构域∶头部结构域是最保守的结构域，它含有与肌动蛋白、ATP结合的位点，负责产生力。与头部相邻的结构域是α螺旋的颈部(α-helical neck region)，它通过同钙调素或类似钙调素的调节轻链亚基的结合来调节头部的活性。尾部结构域含有决定尾部是同膜结合还是同其它的尾部结合的位点，因此它决定是否产生肌球蛋白二聚体还是产生肌球蛋白纤维。
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