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1174664-88-0
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VER-00158411
CAS No. : 1174664-88-0
MCE 国际站：VER-00158411
产品活性：VER-00158411 是一种 CHK1 和 CHK2 抑制剂，IC50 值分别为 4.4 nM 和 4.5 nM。
研究领域：Cell Cycle/DNA Damage
作用靶点：Checkpoint Kinase (Chk)
In Vitro: Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (CHKs). There have been a number of clinical trial of checkpoint kinase inhibits alone or as a combination therapy for example, as a means to sensitize proliferating tumor cells to chemotherapies that damage DNA. The development of checkpoint kinase inhibitors the treatment of cancer was a major objective in drug discovery.
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文献和实验, Bcl 2 and P53 protein xpressions in tissues from hepatocellular carcinoma. Huaren Xiaohua Zazhi,1998;6:834-836 [35] Wang JM, Zou Q, Zou SQ. The role of bcl-2 gene in apoptosis of li ver in rat with obstructive jaundice.Shijie Huaren Xiaohua Zazhi,1999
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