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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1922098-69-8
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1872.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥738.0 |
| 规格： | 5 mg | 产品价格： | ￥1913.0 |
| 规格： | 10 mg | 产品价格： | ￥2975.0 |
| 规格： | 25 mg | 产品价格： | ￥4788.0 |
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CCG-222740
CAS No. : 1922098-69-8
MCE 国际站：CCG-222740
产品活性：CCG-222740 是一种口服有效的，选择性 Rho/MRTF 途径抑制剂。CCG-222740 也是有效的 α-平滑肌肌动蛋白蛋白表达抑制剂。CCG-222740 有效减少皮肤纤维化并阻止黑色素瘤转移。
研究领域：GPCR/G Protein | Cytoskeleton | TGF-beta/Smad | Cell Cycle/DNA Damage | Stem Cell/Wnt
In Vitro: CCG-222740 (10, 20 μM; for 72 hours) increases the protein levels of p27 and decreases cyclin D1. CCG-222740 decreases cell viability of CAFs, with an IC50 of ~10 μM.
CCG-222740 (10, 25 μM) is potent at decreasing αSMA protein expression in human conjunctival fibroblasts.
CCG-222740 has an IC50 of 5 μM in a fibroblast-mediated collagen contraction assay, and it is less cytotoxic.
In Vivo: CCG-222740 (oral gavage; 100 mg/kg/day for 7 days) significantly reduces α-SMA levels in the pancreas of caerulein-stimulated KC mice.
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文献和实验tga cat ccg taa aga cc mouse actin f aac agt ccg cct aga agc ac product size:281 rat actin f TCAGGTCATCACTATCGGCAAT rat actin r AAAGAAAGGGTGTAAAACGCA product size:432 human actin r gag cta cga gct gcc tga cg human actin f cct aga agc att
human actin f ctc cat cct ggc ctc gct gt human actin r gct gtc acc ttc acc gtt cc product size:268 rabbit actin r agt gcg acg tgg aca tcc g rabbit actin f tgg ctc taa cag tcc gcc ta product size:295 mouse actin r cgt tga cat ccg taa aga
:295 mouse actin r cgt tga cat ccg taa aga cc mouse actin f aac agt ccg cct aga agc ac product size:281 rat actin f TCAGGTCATCACTATCGGCAAT rat actin r AAAGAAAGGGTGTAAAACGCA product size:432 human actin r gag cta cga gct gcc tga cg
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