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MCE 国际站:Nucleotide Compound Library
Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.MCE offers a unique collection of 471 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).
Description & Advantages:
• A unique collection of 471 nucleotide/nucleoside and nucleotide/nucleoside analogue compounds.
• A useful tool for the discovery of nucleotide drugs.
• Nucleotide, nucleoside and their structural analogues are included.
• More detailed compound information with structure, IC50, and other chemical & biological data.
• NMR and HPLC validated ensure high purity.
• All compounds are in stock and continuously updated.