- 询价
- Cell Signaling Technology
- 3698
- USA
- 2025年12月19日
- W, IF-IC
- H,M,R,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
p27 Kip1 (SX53G8.5) Mouse mAb
- 抗原：
recombinant human p27 Kip1
- 应用范围：
W, IF-IC
- 供应商：
CST
- 适应物种：
H,M,R,Mk
- 库存：
大量
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IF-IC | H M R Mk | Endogenous | 27 | Mouse IgG1 |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | p27 Kip1 (SX53G8.5) Mouse mAb detects endogenous levels of total p27 Kip1 protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with recombinant human p27 Kip1. Western Blotting
Western blot analysis of extracts from NIH/3T3, C6 and MCF-7 cells using p27 Kip1 (SX53G8.5) Mouse mAb. IF-IC
Confocal immunofluorescent analysis of MCF-7 cells using p27 Kip1 (SX53G8.5) Mouse mAb (green). Actin filaments have been labeled with DY-554 phalloidin (red). |
| Background | p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by treatment with interleukin-2 or other mitogens; this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验-induced responses, including a down-regulation of the cyclin-dependent kinase (Cdk2) inhibitors p21CIP1 and p27KIP1 , while attachment to P-L-L did not. We conclude that engagement of the FN-receptor integrin α5β1 induces integrin signaling regulating
凋亡、抑制血管增生、抑制转移，并且有提高肿瘤细胞对放疗化疗反应的能力[7]。在复发性和难治性肿瘤中显示了较好的疗效。其杀肿瘤细胞存在剂量依赖性。其阻止细胞周期进展主要是通过增加周期蛋白激酶抑制剂（CDKI）p27kip1蛋白水平而诱导细胞停留在G1期[7]。IMC-C225还能抑制肿瘤组织内部的异常血管增生。具有下调肿瘤表达的多种促血管增生因子，如转移生长因子（TGFα）、血管内皮生长因子（VEGF）、白介素-8（IL-8）和纤维生长因子（FGF）等。临床Ⅱ期试验显示明显优于常规治疗法。临床Ⅲ期试验正在
kinase phosphorylates p27kip1 and regulates cell cycle progression. EMBO J. 21(13):3390-3401. Tsuneoka M, Koda Y, Soejima M, Teye K, and Kimura H. (2002). A novel Myc target gene, mina53, that is involved in cell proliferation. J. Biol. Chem. 277(38
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