- 询价
- Cell Signaling Technology
- 4120
- USA
- 2025年11月25日
- W
- H,M,R,Mk
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- 详细信息
- 技术资料
- 抗体英文名：
Microcephalin-1/BRIT1 (D38G5) Rabbit mAb
- 抗原：
synthetic peptide corresponding to central residues of human Microcephalin-1/BRIT1
- 应用范围：
W
- 库存：
大量
- 供应商：
CST
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 适应物种：
H,M,R,Mk
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W | H M R Mk | Endogenous | 100 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Microcephalin-1/BRIT1 (D38G5) Rabbit mAb detects endogenous levels of total Microcephalin-1/BRIT1 protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to central residues of human Microcephalin-1/BRIT1. Western Blotting
Western blot analysis of extracts from various cell types using Microcephalin-1/BRIT1 (D38G5) Rabbit mAb. |
| Background | Microcephalin-1 (MCPH1)/BRIT1 is an early DNA damage response protein named for its mutated state in the human disease primary microcephaly. BRIT1 forms damage-induced nuclear foci, is involved in DNA damage and cell cycle checkpoints as well as regulation of mitosis. BRIT1 function is necessary for DNA damage responses, and the absence of BRIT1 function leads to genome instability. A potential tumor suppressor, BRIT1 expression is reduced in human carcinomas (1-2, reviewed in 3).BRIT1 colocalizes with other DNA repair proteins (53BP1, MDC1, NBS1, ATM, RPA, and ATR) and is required for their activation (2). BRIT1 likely regulates DNA repair through chromatin remodeling in response to DNA damage, allowing access of repair proteins to DNA (4). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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