- 询价
- Cell Signaling Technology
- 2398
- USA
- 2025年11月23日
- W
- Rabbit
- H
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- 详细信息
- 技术资料
- 抗体英文名：
Vav3 Antibody
- 抗原：
synthetic peptide corresponding to the central sequence of human Vav3
- 应用范围：
W
- 宿主：
Rabbit
- 库存：
大量
- 适应物种：
H
- 供应商：
CST
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
40 ul (4 western blots)/100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 40 ul (4 western blots) | 产品价格： | ￥请询价 |
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H | Endogenous | 98 kDa | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Vav3 Antibody detects endogenous levels of total Vav3 protein. The antibody does not cross-react with endogenous levels of other Vav family members. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the central sequence of human Vav3. Antibodies are purified using protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from Jurkat, MCF-7 and HUVEC cells using Vav3 Antibody. |
| Background | Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl homology domain, which confers GEF activity, as well as protein interaction domains that allow them to function in pathways regulating actin cytoskeleton organization (reviewed in 1). Phosphorylation stimulates the GEF activity of Vav protein towards Rho/Rac (2,3). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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