- 询价
- Cell Signaling Technology
- 8701
- USA
- 2025年11月18日
- W, IP, IHC-P
- H,M,R
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- 详细信息
- 技术资料
- 抗体英文名：
eIF4GI (D6A6) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Val418 of human eIF4GI protein
- 应用范围：
W, IP, IHC-P
- 库存：
大量
- 保质期：
详见说明书
- 适应物种：
H,M,R
- 供应商：
CST
- 级别：
详见MSDS文件
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP IHC-P | H M R | Endogenous | 220 | Rabbit IgG |
| Protocols | |
|---|---|
| Specificity / Sensitivity | eIF4GI (D6A6) Rabbit mAb recognizes endogenous levels of total eIF4GI protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val418 of human eIF4GI protein. Western Blotting
Western blot analysis of extracts from various cell lines using eIF4GI (D6A6) Rabbit mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using eIF4GI (D6A6) Rabbit mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human colon carcioma using eIF4GI (D6A6) Rabbit mAb in the presence of control peptide (left) or antigen-specifc peptide (right). 
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using eIF4GI (D6A6) Rabbit mAb. |
| Background | The initiation of translation is an important biological event and a variety of factors contribute to this process. Members of the eIF4 translation initiation factor family bind to the 5' m7 GTP mRNA cap and unwind the mRNA secondary structure (1,2). The amino-terminal portion of eIF4G physically associates with eIF4E to stimulate the binding of eIF4E to the mRNA cap structure (3). eIF4G also interacts with eIF3 and eIF4A and serves as an adaptor molecule in the eIF4 complex (4). Moreover, eIF4G plays a role in internal ribosomal entry site (IRES)-mediated initiation of translation (5,6). The eIF4G family includes eIF4G1 (eIF4GI), eIF4G2 (p97, DAP5 or NAT1), and eIF4G3 (eIF4GII) (7). These factors share a homologous sequence that provides for interaction with initiation factors eIF3 and eIF4A. Both eIF4G1 and eIF4G3 are involved in cap-dependent translation, while eIF4G2 plays a role in IRES-mediated translation of some genes during cell stress (7,8).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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