- 询价
- Cell Signaling Technology
- 8684
- USA
- 2025年11月16日
- W, IP, IHC-P, IF-IC
- H,M,Mk
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- 详细信息
- 技术资料
- 抗体英文名：
CtBP1 (D2D6) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues near the amino terminus of human CtBP1 protein
- 应用范围：
W, IP, IHC-P, IF-IC
- 保质期：
详见说明书
- 适应物种：
H,M,Mk
- 供应商：
CST
- 级别：
详见MSDS文件
- 库存：
大量
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IHC-P=Immunohistochemistry (Paraffin) IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human M=Mouse Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP IHC-P IF-IC | H M Mk | Endogenous | 47 | Rabbit IgG |
| Protocols | |
|---|---|
| Specificity / Sensitivity | CtBP1 (D2D6) Rabbit mAb recognizes endogenous levels of total CtBP1 protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CtBP1 protein. Western Blotting
Western blot analysis of extracts from various cell lines using CtBP1 (D2D6) Rabbit mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using CtBP1 (D2D6) Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lung squamous cell carcinoma using CtBP1 (D2D6) Rabbit mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using CtBP1 (D2D6) Rabbit mAb. IF-IC
Confocal immunofluorescent analysis of 293T cells using CtBP1 (D2D6) Rabbit mAb (green). Actin filaments were labeled with DY-554 phalloidin (red). |
| Background | CtBP1 (C-terminal binding protein 1) was first recognized as a cellular factor that interacts with the C-terminal portion of adenovirus E1A, a protein involved in the transcriptional regulation of key cellular genes (1). CtBP1 is able to regulate gene activity through its intrinsic dehydrogenase activity (2,3) and by interacting with Polycomb Group (PcG) proteins during development (4). Along with its homologue, CtBP2, it acts as a transcriptional corepressor of zinc-finger homeodomain factor deltaEF1 to regulate a wide range of cellular processes through transrepression mechanisms (5). Through its direct interaction with PRDM16, CtBP1 has been shown to be involved in brown adipose tissue differentiation by mediating the repression of white fat genes and directing differentiation toward the brown fat gene program (6). CtBP1 also plays a role in lipid metabolic pathways and membrane fission by regulating the fission machinery operating Golgi tubular networks (7). CtBP1 has recently been shown to repress transcription of BRCA1 via a redox regulated mechanism (8). Furthermore, it is thought that downregulation of BRCA1 and E-cadherin in invasive ductal breast carcinoma correlates directly with activation of CtBP1 (9).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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