- 询价
- Cell Signaling Technology
- 2727
- USA
- 2025年10月22日
- W, IP, IF-IC, F
- H
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- 详细信息
- 技术资料
- 抗体英文名：
SHIP1 (C40G9) Rabbit mAb
- 抗原：
synthetic peptide corresponding to residues surrounding Trp942 of human SHIP1
- 应用范围：
W, IP, IF-IC, F
- 级别：
详见MSDS文件
- 供应商：
CST
- 适应物种：
H
- 库存：
大量
- 保质期：
详见说明书
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation IF-IC=Immunofluorescence (Immunocytochemistry) F=Flow Cytometry
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP IF-IC F | H | Endogenous | 145 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | SHIP1 (C40G9) Rabbit mAb detects the endogenous levels of total SHIP1 protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Trp942 of human SHIP1. Western Blotting
Western blot analysis of total extracts from RL and Molt4 cells using SHIP1 (C40G9) Rabbit mAb. Flow Cytometry
Flow cytometric analysis of Jurkat cells (red) and RL cells (blue) using SHIP1 (C40G9) Rabbit mAb. IF-IC
Confocal immunofluorescent analysis of RL (left) and Jurkat cells (right) using SHIP1 (C40G9) Rabbit mAb (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). |
| Background | SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate (1). SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus (1,2). Upon receptor cross-linking, SHIP is first recruited to the membrane junction through binding of its SH2 domain to the phospho-tyrosine in the ITIM motif (2), followed by tyrosine phosphorylation on the NPXY motif (2). The membrane relocalization and phosphorylation on the NPXY motif is essential for the regulatory function of SHIP1 (3-5). Its effect on calcium flux, cell survival, growth, cell cycle arrest and apoptosis is mediated through the PI3K and Akt pathways (3-5). Tyr1021 is located in one of the NPXY motifs in SHIP1, and its phosphorylation is important for SHIP1 function (6).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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