- ￥3000 - 3999
- Abbiotec
- 美国
- 253079
- 2025年07月07日
- WB, IHC, IF
- Mouse
- H, Mk
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified recombinant fragment of human CRTC2 expressed in E. coli.
- 亚型：
Mouse IgG1
- 形态：
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
- 保存条件：
Store at -20°C
- 克隆性：
单克隆
- 标记物：
见下方详细说明
- 适应物种：
H, Mk
- 保质期：
1-2年
- 抗原来源：
Purified recombinant fragment of human CRTC2 expressed in E. coli.
- 目录编号：
253079
- 级别：
超纯
- 库存：
大量
- 供应商：
Abbiotec
- 宿主：
Mouse
- 应用范围：
WB, IHC, IF
- 浓度：
见详细说明信息
- 靶点：
CRTC2 (5B10)
- 抗体英文名：
CRTC2 (5B10) Antibody
- 抗体名：
CRTC2 (5B10) Antibody
- 规格：
0.1 ml
CRTC2 (5B10) Antibody产品详细介绍：
| 产品名称： | CRTC2 (5B10) Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 253079 |
| 规格： | 0.1 ml |
| 产品描述： | CRTC2 (CREB-regulated transcription coactivator 2, Torc2) is a CREB coactivator, regulating glucose homeaostatis. Glucose homeostasis is regulated by hormones and cellular energy status. Elevations of blood glucose during feeding stimulate insulin release from pancreatic β-cells through a glucose sensing pathway. Feeding also stimulates release of gut hormones such as glucagon-like peptide-1 (GLP-1), which further induces insulin release, inhibits glucagon release and promotes β-cell viability. CREB-dependent transcription likely plays a role in both glucose sensing and GLP-1 signaling. Torc2 is implicated in mediating the effects of these two pathways. In quiescent cells, Torc2 is phosphorylated at Ser171 and becomes sequestered in the cytoplasm via an interaction with 14-3-3 proteins. Glucose and gut hormones lead to the dephosphorylation of Torc2 and its dissociation from 14-3-3 proteins. Dephosphorylated Torc2 enters the nucleus to promote CREB-dependent transcription. Torc2 plays a key role in the regulation of hepatic gluconeogenic gene transcription in response to hormonal and energy signals during fasting.Torc2 is most abundantly expressed in the thymus. Present in both B and T lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. |
| 克隆类型： | Mouse Monoclonal Antibody |
| 亚型： | Mouse IgG1 |
| 免疫原： | Purified recombinant fragment of human CRTC2 expressed in E. coli. |
| 适用物种： | H, Mk |
| 应用范围： | WB, IHC, IF |
| 应用说明： | WB: 1:500-1:2000; IF: 1:200-1:1000; IHC: 1:200-1:1000; |
| 别名： | CREB-regulated transcription coactivator 2; Transducer of regulated cAMP response element-binding protein 2; TORC-2; Transducer of CREB protein 2 TORC2; CRTC2; |
| 形态： | Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件： | Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 参考文献： |
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文献和实验(1 ). In our laboratory, we have developed methods to immortalize specific antibody-producing cells by fusing secreting EBV-activated lymphocytes to mouse-human heteromyeloma cell lines with electrofusion, followed by cloning (2 ). This methodology has allowed
secondary antibody review -- data from 99 publications
cytometry used as a control to detect cell responses targeted antigen 7 Alexa Fluor 488 7 Cy3 8 goat IgG Alexa Fluor 488 1:2000 detect antibody binding in human embryonic kidney 293T cells Invitrogen 9 donkey
指二个以上系统之间有一部分基因不同而其它基因都相同的纯系鼠，例如 C57BL／ 10（ H－ 2b ）系与 DBA／ 2（ H－ 2d ）系为不同的系统，但 C57BL／ 10鼠的 H－ 2基因用 DBA／ 2的同基因置换了的 B10． D2鼠，有 H－ 2d ，但其它基因与 C57BL／ 10是相同的，称 B10． D2与 C57BL／ 10为同族。这种仅 H－ 2基因不同的情况称同族抵抗鼠（ congenic resistant mou-se）。同族关系并不限与 H－
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