- ￥3000 - 3999
- Abbiotec
- 美国
- 252954
- 2025年07月14日
- WB
- Mouse
- H
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- 详细信息
- 技术资料
- 免疫原：
Purified recombinant fragment of human HAUSP expressed in E. coli. <br> <br>
- 亚型：
Mouse IgG1
- 形态：
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
- 保存条件：
Store at -20°C
- 克隆性：
单克隆
- 标记物：
见下方详细说明
- 适应物种：
H
- 保质期：
1-2年
- 抗原来源：
Purified recombinant fragment of human HAUSP expressed in E. coli. <br> <br>
- 目录编号：
252954
- 级别：
超纯
- 库存：
大量
- 供应商：
Abbiotec
- 宿主：
Mouse
- 应用范围：
WB
- 浓度：
见详细说明信息
- 靶点：
HAUSP (5F11)
- 抗体英文名：
HAUSP (5F11) Antibody
- 抗体名：
HAUSP (5F11) Antibody
- 规格：
0.1 ml
HAUSP (5F11) Antibody产品详细介绍：
| 产品名称： | HAUSP (5F11) Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 252954 |
| 规格： | 0.1 ml |
| 产品描述： | HAUSP (Herpesvirus-associated ubiquitin-specific protease) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase and for the tumor suppressor protein p53. Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults. |
| 克隆类型： | Mouse Monoclonal Antibody |
| 亚型： | Mouse IgG1 |
| 免疫原： | Purified recombinant fragment of human HAUSP expressed in E. coli. |
| 适用物种： | H |
| 应用范围： | WB |
| 应用说明： | WB: 1:500-1:2000; |
| 别名： | Ubiquitin carboxyl-terminal hydrolase 7; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7; HAUSP; USP7 |
| 形态： | Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件： | Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 参考文献： |
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HAUSP (5F11) Antibody_HAUSP (5F11)抗体
￥3000 - 3999
