N-trans-FeruloyltyramineN-反式-阿

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N-trans-Feruloyltyramine

CAS No. : 66648-43-9

MCE 国际站：N-trans-Feruloyltyramine

产品活性：N-trans-Feruloyltyramine (N-feruloyltyramine) 是一种生物碱，是一种有效的抗氧化剂。N-trans-Feruloyltyramine 可以改善 H₂O₂ 诱导的细胞内 ROS 生成并减少细胞凋亡。N-trans-Feruloyltyramine 具有用于氧化应激相关神经退行性疾病和癌症研究的潜力。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Reactive Oxygen Species  |  Apoptosis

In Vitro: N-trans-Feruloyltyramine (N-feruloyltyramine; 10-500 µM; 3 hours prior H₂O₂) protects the cells against H₂O₂-induced toxicity.
N-trans-Feruloyltyramine (25-100 µM; 3 hours prior H₂O₂) with 100 µM significantly reduces Bax and activated caspase-3 levels in H₂O₂-treated SK-N-SH cells.
N-trans-Feruloyltyramine significantly improves an H₂O₂-mediated increase in ROS levels.
N-trans-Feruloyltyramine (10-500 µM) does not affect viability of the SK-N-SH cells.
N-trans-Feruloyltyramine (64-320 µM; 24 hours) shows proliferation inhibition on HepG2 cells with IC₅₀ value of 194 µM.

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