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- 2025年07月14日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
(±)-10-HCPT
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
64439-81-2
- 规格：
5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 5 mg | 产品价格： | ￥312.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥500.0 |
| 规格： | 25 mg | 产品价格： | ￥700.0 |
| 规格： | 50 mg | 产品价格： | ￥1000.0 |
| 规格： | 100 mg | 产品价格： | ￥1400.0 |
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(±)-10-Hydroxycamptothecin
CAS No. : 64439-81-2
MCE 国际站：(±)-10-Hydroxycamptothecin
产品活性：(±)-10-Hydroxycamptothecin 是一种生物碱，能够抑制拓扑异构酶 I (topoisomerase I) 的活性，具有广谱的抗肿瘤活性。
研究领域：Cell Cycle/DNA Damage
作用靶点：Topoisomerase
In Vitro: (±)-10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor of topo I. (±)-10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedly inhibits the proliferation of Colo 205 cells in a dose-dependent manner. (±)-10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cells in the G2 phase of the cell cycle and triggers apoptosis through a caspase-3-dependent pathway. (±)-10-Hydroxycamptothecin (HPT, 0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation and condensed chromosomes and induces apoptosis of human urinary bladder cancer cell line (T24).
In Vivo: (±)-10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.) significantly suppresss tumor growth in mouse xenografts. (±)-10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4 days) causes no obvious acute toxicity in nude mice.
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