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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
(+)-3,4-Didehydrocoronaridine Tartrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
4168-17-6
- 规格：
10 mM * 1 mL/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥330.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥300.0 |
| 规格： | 100 mg | 产品价格： | ￥450.0 |
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Catharanthine Tartrate
CAS No. : 4168-17-6
MCE 国际站：Catharanthine Tartrate
产品活性：Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate 是抗癌长春花生物碱的一种成分，可抑制电压驱动的 L 型 Ca2+ 通道 (VOCC)。Catharanthine Tartrate 对心肌细胞和血管平滑肌细胞 (VSMC) 中 VOCC 电流的 IC50 分别为 220 μM 和 8 μM。Catharanthine Tartrate 可降低血压 (BP)、心率 (HR)。Catharanthine Tartrate 具有抗癌活性。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：Calcium Channel
In Vivo: Catharanthine ((+)-3,4-Didehydrocoronaridine; 0.5-20 mg/kg; IV; single dose) Tartrate evokes dose-dependent reductions in both BP and HR.
Catharanthine (40 mg/kg; ip; single dose) Tartrate with acute administration induces similar antidepressant-like activity in male and female mice at 1 h and 24 h.
Catharanthine (20 mg/kg; ip; for 14 consecutive days) Tartrate increases swimming time and decreases immobility time at D7 or D14 in mice.
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