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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
(+)-3,4-Didehydrocoronaridine
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2468-21-5
- 规格：
10 mM * 1 mL/25 mg/50 mg/100 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥356.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥324.0 |
| 规格： | 50 mg | 产品价格： | ￥465.0 |
| 规格： | 100 mg | 产品价格： | ￥650.0 |
| 规格： | 500 mg | 产品价格： | ￥1650.0 |
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Catharanthine
CAS No. : 2468-21-5
MCE 国际站：Catharanthine
产品活性：Catharanthine ((+)-3,4-Didehydrocoronaridine) 是抗癌长春花生物碱的一种成分，可抑制电压驱动的 L 型 Ca2+ 通道 (VOCC)。Catharanthine 对心肌细胞和血管平滑肌细胞 (VSMC) 中 VOCC 电流的 IC50 分别为 220 μM 和 8 μM。Catharanthine 可降低血压 (BP)、心率 (HR)。Catharanthine 具有抗癌活性。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：Calcium Channel
In Vivo: Catharanthine ((+)-3,4-Didehydrocoronaridine; 0.5-20 mg/kg; IV; single dose) evokes dose-dependent reductions in both BP and HR.
Catharanthine (40 mg/kg; ip; single dose) with acute administration induces similar antidepressant-like activity in male and female mice at 1 h and 24 h.
Catharanthine (20 mg/kg; ip; for 14 consecutive days) increases swimming time and decreases immobility time at D7 or D14 in mice.
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