Swainsonine苦马豆碱,72741-87-8

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Swainsonine

CAS No. : 72741-87-8

MCE 国际站：Swainsonine

产品活性：Swainsonine (Tridolgosir) 是一种天然的吲哚里西啶生物碱，是一种有效且可逆的 α-甘露糖苷酶 （α-mannosidase） 抑制剂。Swainsonine 诱导细胞凋亡 （apoptosis）和细胞周期停滞在 G2/M 期。Swainsonine 具有抗肿瘤活性。

研究领域：Apoptosis  |  Anti-infection

作用靶点：Apoptosis  |  Antibiotic

In Vitro: Swainsonine (0-40 μM; 12 h) shows antiproliferative activity in U251 and LN444 cells.
Swainsonine (30 μM; 12 h) induces apoptosis and cell cycle arrest at G2/M phase, and decreases the expression of CyclinD1 and CDK4 protein levels, increases the expression of p16 protein level.
Swainsonine (30 μM; 12 h) reduces glioma cell migration and invasion.

In Vivo: Swainsonine (1 mg/kg; i.p.; twice daily for ten days) and cisplatin increases the anti-tumor efficacy in mouse.

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