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SNAP 94847
CAS No. : 487051-12-7
MCE 国际站：SNAP 94847
产品活性：SNAP 94847 是一种新型的，高亲和力的选择性黑色素浓缩激素受体 1 (MCHR1) 拮抗剂，其 (Ki= 2.2 nM, Kd=530 pM)，它对 MCHα1A 和 MCHD2 受体分别显示出 >80 倍和 >500 倍的选择性。 SNAP 94847 以高亲和力与小鼠和大鼠 MCHR1 结合，与其他 GPCR，离子通道，酶和转运蛋白的交叉反应性很小。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：MCHR1 (GPR24)
In Vivo: SNAP 94847 (oral gavage; 20 mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment: F(2,19)=11.31, treatment × time: F(34,323) = 4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals.
SNAP 94847 (oral administration; 20 mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment: F(3,28) = 8.971; treatment × time: F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40 min in the SNAP 94847-treated group,this effect is significant over 180 min.
SNAP 94847 (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study.
相关产品：SNAP 94847 hydrochloride | Melanin Concentrating Hormone, salmon TFA | MCH(human, mouse, rat) TFA | AZD1979 | [Ala17]-MCH | ALB-127158(a) | Ethyl linolenate | GW-803430 | MCH-1 antagonist 1 | MCHR1 antagonist 2 | TC-MCH 7c | (Phe13,Tyr19)-MCH (human, mouse, rat) | Ac-hMCH(6-16)-NH2 | AMG-076 | ATC0175 | BMS-814580 | hMCH-1R antagonist 1 | MCHR1 antagonist 3 | Neuropeptide EI, rat | BMS-819881 | MCHR1 antagonist 1 | NGD-4715 | SB-568849
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文献和实验New England Biolabs（NEB 公司）隆重推出蛋白质标记 SNAP-tag 最新技术，该项技术可以在活细胞及固定细胞中研究蛋白质的功能和定位。SNAP-tag 技术能将哺乳动物细胞体内蛋白质成像并且体外捕获蛋白质，为研究蛋白质提供了强有力的工具。 其工作原理是：构建基因，表达融合蛋白质，再与多种荧光基团、生物素或磁珠形成共价结合。为了使用方便，NEB 提供两套系统：一套是标记物可以直接自我标记构建好的融合蛋白质（SNAP-tag 和 CLIP-tag），另一套是标记
Site‐Specific Protein Labeling with SNAP‐Tags
and specificities and provide flexibility not available with fluorescent proteins. The SNAP?tag is a modified form of the DNA repair enzyme human O 6 ?alkylguanine?DNA?alkyltransferase, and undergoes a self?labeling reaction to form a covalent bond with O
Antisense Blockade of Expression: SNAP-25 In Vitro and In Vivo
With the advent of modern molecular genetics and molecular biology, we will face more and more situations where novel gene products with unknown functions are identified. Genetic linkage analysis will allow the association of novel or known
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