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- 保存条件:
4°C, sealed storage, away from moisture
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- 规格:
10 mM * 1 mL/5 mg/10 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥2850.0 |
|---|---|---|---|
| 规格: | 5 mg | 产品价格: | ¥2400.0 |
| 规格: | 10 mg | 产品价格: | ¥3400.0 |
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ZM223 hydrochloride
CAS No. : 2438679-27-5
MCE 国际站:ZM223 hydrochloride
产品活性:ZM223 hydrochloride 是一种有效的非共价 NEDD8 活化酶 (NAE) 抑制剂,具有口服活性。
研究领域:Metabolic Enzyme/Protease
作用靶点:NEDD8-activating Enzyme
In Vitro: ZM223 hydrochloride (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively.
ZM223 hydrochloride (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex.
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analysis and integration: of steps and arrows. Nat Genet, 22(3): 213-5. 17• Boguski MS. 1998. Data management and analysis for gene expression arrays. Nat. Genet., 20:1923. 18• Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C
** 8,887 20,645 1.32*** 9,064 18,019 0.99** 8,870 19,506 1.20** hsa-miR-27b 10,067 22,544 1.24** 11,924 23,914 1.01*** 11,564 23,044 0.99*** 12,182 24,515 1.01** microRNAs rated higher in ME-15 hsa-miR-146
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