产品货号:jlcR18280 英文名称 :LIN54 中文名称 :LIN54蛋白抗体 别 名 : CXC domain-containing protein 1; CXCDC1; DKFZp686L1814; JC8.6; KIAA2037; Lin54; LIN54_HUMAN; MGC129905; MIP120; Protein lin-54 homolog. 研究领域 :肿瘤 细胞生物 免疫学 转录调节因子 表观遗传学 抗体来源 :Rabbit 克隆类型 : Polyclonal 交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 :80kDa 细胞定位 :细胞核 性 状 :Lyophilized or Liquid 浓 度 :1mg/ml 免 疫 原 : KLH conjugated synthetic peptide derived from human LIN54:101-200/749 亚 型 :IgG 纯化方法 :affinity purified by Protein A 储 存 液 :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 :Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed : PubMed 产品介绍 : LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
Function: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner.
Subcellular Location: Nucleus.
Similarity: Belongs to the lin-54 family. Contains 2 CXC domains.
SWISS: Q6MZP7
Gene ID: 132660
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.