- ￥1600 - 2650
- MultiSciences
- 0.31 ng/mL - 20 ng/mL
- 杭州
- EK2173
- 2026年03月23日
企业认证
研选同类产品更多 >
Mouse CCL2/MCP-1 High Sensitivity ELISA Kit（小鼠趋化因子配体2/单核细胞趋化蛋白1 高敏ELISA试剂盒）
￥1600
Mouse myeloperoxidase/MPO ELISA Kit（ 小鼠髓过氧化物酶试剂盒）
￥1600
Mouse CCL2/MCP-1 ELISA Kit（小鼠趋化因子配体2/单核细胞趋化蛋白1试剂盒）
￥1600
Mouse IL-4 High Sensitivity ELISA Kit（小鼠白介素4 高敏ELISA试剂盒）
￥2000
Mouse IL-1β High Sensitivity ELISA Kit（小鼠白介素1β高敏ELISA试剂盒）
￥2000
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 用户评价
- 文献和实验
- 技术资料
- 库存：
99
- 供应商：
联科生物
- 检测范围：
0.31 ng/mL - 20 ng/mL
- 检测方法：
双抗夹心法
- 应用：
ELISA
- 适应物种：
Mouse
- 标记物：
HRP
- 样本：
血清，血浆，细胞培养上清及其他生物学样本
- 规格：
96T/48T
| 规格： | 96T | 产品价格： | ￥2650.0 |
|---|---|---|---|
| 规格： | 48T | 产品价格： | ￥1600.0 |
| 背景介绍 | 颗粒酶B(GranzymeB)是一种丝氨酸蛋白酶，最常见于细胞毒性淋巴细胞(CTLs)和自然杀伤细胞(NK细胞)颗粒中。由这些细胞分泌的GranzymeB和穿孔蛋白一起作用介导靶细胞的凋亡。最近，人们发现许多非细胞毒性细胞从嗜碱性粒细胞、肥大细胞到平滑肌细胞也可产生GranzymeB。GranzymeB通过刺激细胞因子的释放参与诱导炎症，同样也参与细胞外基质重塑。升高的GranzymeB水平与许多自身免疫性疾病、一些皮肤病和1型糖尿病有关。 |
| 检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附法定量检测小鼠Granzyme B。小鼠Granzyme B试剂盒仅供科学研究，不用于临床诊断。 颗粒酶 B (Granzyme B)是一种丝氨酸蛋白酶，最常见于细胞毒性淋巴细胞(CTLs)和自然杀伤 细胞(NK 细胞)颗粒中。 由这些细胞分泌的 Granzyme B 和穿孔蛋白一起作用介导靶细胞的凋亡。 最近，人们发现许多非细胞毒性细胞从嗜碱性粒细胞、肥大细胞到平滑肌细胞也可产生 Granzyme B。 Granzyme B 通过刺激细胞因子的释放参与诱导炎症， 同样也参与细胞外基质重塑。 升高的 Granzyme B 水平与许多自身免疫性疾病、 一些皮肤病和 1 型糖尿病有关。 |
| 组分 | 包被抗Granzyme B单克隆抗体的96孔聚苯乙烯酶标板 小鼠Granzyme B冻干标准品 Granzyme B检测抗体 辣根过氧化物酶标记的链霉亲和素 检测缓冲液(10×) 底物(TMB) 终止液 洗液(20×) 封板膜 |
| 分析类型 | 夹心ELISA |
| 样本类型 | 血清、血浆，细胞培养上清及其他生物学样本 |
| 板式 | 96孔板，可拆 |
| 保存 | 试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。 |
| 运输条件 | 4℃蓝冰运输 |
| 样本体积 | 10 μl |
| 灵敏度 | 0.91 pg/ml |
| 标曲图 |  |
| 标准曲线范围 | 0.31 - 20ng/ml |
| 回收率范围 | 91 %-105 % |
| 平均回收率 | 0.99 |
| 板间变异系数 | 1.8 % - 2.8 % |
| 板内变异系数 | 2.9 % - 3.9 % |
GZMB 分子靶点信息概述
- 分子名：GZMB, granzyme B
- 基因家族：Granule associated serine proteases of immune defence
- 别名：CCPI; CGL-1; CSP-B; CGL1; CTSGL1; HLP; SECT
- 曾用名：CTLA1; CSPB
- 全称：fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cell serine protease 1-3E; granzyme 2; cytotoxic T-lymphocyte-associated serine esterase 1; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMB 分子靶点综述
颗粒酶B(GranzymeB)是一种丝氨酸蛋白酶，最常见于细胞毒性淋巴细胞(CTLs)和自然杀伤细胞(NK细胞)颗粒中。由这些细胞分泌的GranzymeB和穿孔蛋白一起作用介导靶细胞的凋亡。最近，人们发现许多非细胞毒性细胞从嗜碱性粒细胞、肥大细胞到平滑肌细胞也可产生GranzymeB。GranzymeB通过刺激细胞因子的释放参与诱导炎症，同样也参与细胞外基质重塑。升高的GranzymeB水平与许多自身免疫性疾病、一些皮肤病和1型糖尿病有关。
小鼠 Mouse Gzme 分子靶点信息
- 分子名：Gzme, granzyme E
- 别称：
- CCP3
- Ctla-6
- Ctla6
- cytotoxic T lymphocyte-associated protein 6
- MCSP-2
- 基因序列：NCBI_Gene: 14942
- 蛋白序列：
- UniprotKB: P08884
小鼠 Mouse Gzme 靶点分子功能（预测）
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptosis. Predicted to act upstream of or within cytolysis. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in extraembryonic component; placenta; spongiotrophoblast; and trophoblast giant cell. Orthologous to human GZMB (granzyme B).
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
用户评价
暂无用户评价
文献和实验- IF = 47.728 Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop. SCIENCE (2021)
- IF = 15.881 Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy. ACS Nano (2021)
- IF = 14.919 METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells. Nature Communications (2021)
- IF = 10.107 Coexpression of IL7 and CCL21 Increases Efficacy of CAR-T Cells in Solid Tumors without Requiring Preconditioned LymphodepletionIL7 and CCL21 Enhance Antitumor Efficacy of CAR-T Cells. CLINICAL CANCER RESEARCH (2020)
- IF = 9.933 A Vaccination with Boosted Cross Presentation by ER-Targeted Antigen Delivery for Anti-Tumor Immunotherapy. Advanced Healthcare Materials (2021)
- IF = 9.423 Tumor-derived Jagged1 promotes cancer progression through immune evasion. Cell Reports (2022)
- IF = 8.986 Olaparib Suppresses MDSC Recruitment via SDF1α/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice. MOLECULAR THERAPY (2020)
- IF = 8.786 Inhibition of PCSK9 enhances the antitumor effect of PD-1 inhibitor in colorectal cancer by promoting the infiltration of CD8+ T cells and the exclusion of Treg cells. Frontiers in Immunology (2022)
- IF = 7.723 CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy. OncoImmunology (2022)
- IF = 7.396 Cytotoxic T lymphocyte-associated protein 4 antibody aggrandizes antitumor immune response of oncolytic virus M1 via targeting regulatory T cells. INTERNATIONAL JOURNAL OF CANCER (2021)
- IF = 6.51 Lycium barbarum polysaccharides-loaded Particulate Alum via Pickering emulsion as an adjuvant to enhance immune responses. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)
- IF = 6.304 Intravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade. Cell Death & Disease (2020)
- IF = 5.999 Pickering emulsion stabilized by Chinese Yam polysaccharides PLGA for enhanced humoral and cellular immune responses. COLLOIDS AND SURFACES B-BIOINTERFACES (2022)
- IF = 4.939 Administration Routes of Polyethylenimine-Coated PLGA Nanoparticles Encapsulating Angelica Sinensis Polysaccharide Vaccine Delivery System Affect Immune Responses. MOLECULAR PHARMACEUTICS (2021)
- IF = 4.372 Resveratrol ameliorates Lewis lung carcinoma-bearing mice development, decreases granulocytic myeloid-derived suppressor cell accumulation and impairs its suppressive ability. CANCER SCIENCE (2018)
- IF = 4.178 Damage-induced NAD release activates intestinal CD4+ and CD8+ T cell via P2X7R signaling. CELLULAR IMMUNOLOGY (2023)
- IF = 3.743 Antitumor efficacy of chimeric antigen receptor T cells against EGFRvIII-expressing glioblastoma in C57BL/6 mice. BIOMEDICINE & PHARMACOTHERAPY (2019)
Detection of Human and Mouse Granzyme B Activity in Cell Extracts
The serine protease granzyme B (GrB) is a key effector molecule in cell-mediated immunity, released by cytotoxic lymphocytes (CLs) to induce cell death in neoplastic or virus-infected cells. The ability to detect and measure GrB activity
RAT/MOUSE GROWTH HORMONE ELISA KIT
实验原理 This assay is a Sandwich ELISA based, sequentially, on: 1) capture of rat or mouse Growth Hormone molecules from samples to the wells of a microtiter plate coated by a pre-titered amount of anti-Growth Hormone
Immunodetection of Granzyme B Tissue Distribution and Cellular Localisation
Investigation of Granzyme B (GrB) function and pathophysiology in both human settings and rodent models increasingly involve the use of indirect immunofluorescence imaging and fluorescence-activated cell sorting, which requires reliable GrB
技术资料需要更多技术资料 索取更多技术资料
