- ￥2260
- LSM Bio
- 进口
- PAab09940
- 2025年07月17日
- ELISA, IF, WB
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
hypoxia inducible factor 1, alpha subunit(basic helix-loop-helix transcription factor)
- 亚型：
IgG1
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
monoclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Mouse
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, IF, WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
hypoxia inducible factor 1, alpha subunit(basic helix-loop-helix transcription factor)
- 抗体英文名：
HIF1a antibody
- 抗体名：
HIF1a antibody
- 规格：
100μl
HIF1a antibody
Product Name HIF1a antibody
Catalog No PAab09940
Packing 100ul
Form liquid
Alternative Name BHLHE78, MOP1, PASD8
Purification protein A+G purified
Purity 95% as determined by SDS-PAGE
Host Mouse
Isotype IgG1
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Under normal oxygen conditions, HIF1a is continuously produced and destroyed, in a process involving hydroxylation, interaction with von Hippel-Lindau (VHL) protein, polyubiquitylation and subsequent proteasomal degradation. Under hypoxic conditions, hydroxylation is impaired and HIF1a is stabilized. HIF1a localizes in cytoplasm in normoxia, but it can translocate into nuclear in response to hypoxia. The calculated molecular weight of HIF1a is 93 kDa, but the modified protein HIF1a is about 110-120kDa (PMID: 11698256, .PMID: 7539918).
Immunogen hypoxia inducible factor 1, alpha subunit(basic helix-loop-helix transcription factor)
Specificity Human
Tested Application ELISA, IF, WB
Recommended dilution WB: 1:1000-1:10000; IF: 1:50-1:200
IHC use
WB use
Cobalt Chloride treated HeLa cells were subjected to SDS PAGE followed by western blot with PAab09940(HIF1a Antibody) at dilution of 1:5000
Protein Information
Gene ID 3091
Uniprot ID Q16665
Calculated MW 120 kDa
Research Area Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience, Stem Cells
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease
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