- ￥2260
- LSM Bio
- 进口
- PAab10066
- 2025年07月07日
- ELISA, IHC
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
DNA replication helicase 2 homolog
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
DNA replication helicase 2 homolog
- 抗体英文名：
DNA2 antibody
- 抗体名：
DNA2 antibody
- 规格：
100μl
DNA2 antibody
Product Name DNA2 antibody
Catalog No PAab10066
Packing 100ul
Form liquid
Alternative Name DNA2, DNA2L, KIAA0083
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex(RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break(DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA(ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
Immunogen DNA replication helicase 2 homolog
Specificity Human
Tested Application ELISA, IHC
Recommended dilution IHC: 1:20-1:200
IHC use Immunohistochemistry of paraffin-embedded human colon cancer using PAab10066(DNA2 antibody) at dilution of 1:100
WB use
Protein Information
Gene ID 1763
Uniprot ID P51530
Calculated MW 127 kDa
Research Area Metabolism
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
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The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease
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