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- 1.56 pg/mL - 100 pg/mL
- 杭州
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- 2025年12月11日
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- 技术资料
- 库存：
99
- 供应商：
联科生物
- 检测范围：
1.56 pg/mL - 100 pg/mL
- 检测方法：
双抗夹心法
- 应用：
ELISA
- 适应物种：
Human
- 标记物：
HRP
- 样本：
血清，血浆，细胞培养上清及其他生物学样本
- 规格：
96T/48T
| 规格： | 96T | 产品价格： | ￥2650.0 |
|---|---|---|---|
| 规格： | 48T | 产品价格： | ￥1600.0 |
| 背景介绍 | 肿瘤坏死因子α(TNF-α)也称为恶病质素和TNFSF1A，是一种脂肪因子，参与全身的炎症，同时也是刺激急性期反应的细胞因子之一。它主要由活化的巨噬细胞产生，也可由其它类型的细胞分泌，如CD4+淋巴细胞、NK细胞、中性粒细胞、肥大细胞、嗜酸性粒细胞和神经元等。它在免疫应答中具有多种调节功能，还可作为潜在的热原。TNF-α对刺激物(感染因子或组织受损)产生应答后，在全身循环，激活中性粒细胞，改变血管内皮细胞的特性，调控其它组织的代谢活性，以及通过诱导局部凝血作用展现肿瘤杀伤活性。TNF-α在关节组织和其它组织发生炎症的发病机制具有重要作用。最近，越来越多的信息表明TNF-α也参与了AIDS的发病机制。TNF-α的测定对于移植研究也非常有用。 |
| 检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人TNF-α抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的TNF-α与固相抗体结合。洗涤去除未结合的物质后，加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体，加入辣根过氧化物酶标记的链霉亲和素 (Streptavidin-HRP)。洗涤后，加入信号增强剂孵育，洗涤去除未结合的物质后，再次加入Streptavidin-HRP。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中TNF-α的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。 |
| 组分 | 包被抗TNF-α单克隆抗体的96孔聚苯乙烯酶标板 人TNF-α冻干标准品 TNF-α检测抗体 标准品稀释液 辣根过氧化物酶标记的链霉亲和素 信号增强剂浓缩液 信号增强剂稀释液 检测缓冲液(10×) 底物(TMB) 终止液 洗液(20×) |
| 分析类型 | 夹心ELISA |
| 样本类型 | 血清、血浆，细胞培养上清及其他生物学样本 |
| 板式 | 96孔板，可拆 |
| 保存 | 试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。 |
| 运输条件 | 4℃蓝冰运输 |
| 样本体积 | 血清血浆：20 μl 细胞培养上清：100μl |
| 灵敏度 | 0.16pg/ml |
| 标准曲线范围 | 1.56-100pg/ml |
| 回收率范围 | 100%-108% |
| 平均回收率 | 1.04 |
| 板间变异系数 | 5.4 % - 7.0% |
| 板内变异系数 | 4.1% -4.8 % |
TNF 分子靶点信息概述
- 分子名：TNF, tumor necrosis factor
- 基因家族：Tumor necrosis factor superfamily
- 别名：TNFSF2; DIF; TNF-alpha
- 曾用名：TNFA
- 全称：TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2)
TNF 分子靶点综述
TNF-α 为单核细胞、巨噬细胞、中性粒细胞、NK 细胞和 CD4+T 细胞产生的 17 kDa 细胞因子。它在免疫应答中具有多种调节功能，还可作为潜在的热原。TNF-α对刺激物(感染因子或组织受损)产生应答后，在全身循环，激活中性粒细胞，改变血管内皮细胞的特性，调控其它组织的代谢活性，以及通过诱导局部凝血作用展现肿瘤杀伤活性。TNF-α 在关节组织和其它组织发生炎症的发病机制具有重要作用。
人 Human TNF 分子靶点信息
- 分子名：TNF, tumor necrosis factor
- 别称：
- APC1 protein
- cachectin
- DIF
- TNF superfamily, member 2
- TNF-a
- TNF-alpha
- TNF, macrophage-derived
- TNF, monocyte-derived
- TNFA
- TNFSF2
- TNLG1F
- tumor necrosis factor alpha
- tumor necrosis factor ligand 1F
- tumor necrosis factor ligand superfamily member 2
- tumor necrosis factor-alpha
- 基因序列：NCBI_Gene: 7124
- 蛋白序列：UniProtKB: P01375
人 Human TNF靶点分子功能（预测）
Enables several functions, including identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of macromolecule metabolic process; and regulation of apoptotic process. Acts upstream of or within several processes, including regulation of cellular protein metabolic process; regulation of gene expression; and regulation of signal transduction. Located in cell surface; extracellular space; and membrane raft. Is integral component of plasma membrane. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Biomarker of several diseases, including anemia (multiple); autoimmune disease (multiple); eye disease (multiple); kidney disease (multiple); and lung disease (multiple).
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- IF = 4.932 Inhibition of microRNA-92a ameliorates lipopolysaccharide-induced endothelial barrier dysfunction by targeting ITGA5 through the PI3K/Akt signaling pathway in human pulmonary microvascular endothelial cells. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
- IF = 3.212 Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes. INFLAMMATION (2020)
- IF = 3.143 Interleukin-21 Inhibits HBV Replication in vitro:. ANTIVIRAL THERAPY (2014)
- IF = 3.361 Interleukin-25 is upregulated in patients with systemic lupus erythematosus and ameliorates murine lupus by inhibiting inflammatory cytokine production. INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
- IF = 5.714 Interleukin-37 ameliorates atherosclerosis by regulating autophagy-mediated endothelial cell apoptosis and inflammation. INTERNATIONAL IMMUNOPHARMACOLOGY (2023)
- IF = 4.4 Isobaric Tags for Relative and Absolute Quantitation (iTRAQ)-Based Proteomic Analysis of Hugan Qingzhi and Its Protective Properties against Free Fatty Acid-Induced L02 Hepatocyte Injury. Frontiers in Pharmacology (2017)
- IF = 2.886 JAK-STAT Domain Enhanced MUC1-CAR-T Cells Induced Esophageal Cancer Elimination. Cancer Management and Research (2020)
- IF = 2.592 Levels of Interleukin-1β, Interleukin-18, and Tumor Necrosis Factor-α in Cerebrospinal Fluid of Aneurysmal Subarachnoid Hemorrhage Patients May Be Predictors of Early Brain Injury and Clinical Prognosis. World Neurosurgery (2017)
- IF = 2.472 Lipopolysaccharide from biofilm-forming Pseudomonas aeruginosa PAO1 induces macrophage hyperinflammatory responses. JOURNAL OF MEDICAL MICROBIOLOGY (2021)
- IF = 3.242 Liraglutide regulates bone destruction and exhibits anti-inflammatory effects in periodontitis in vitro and in vivo. JOURNAL OF DENTISTRY (2020)
- IF = 2.1 lncRNA SNHG16 promotes the occurrence of osteoarthritis by sponging miR‑373‑3p. Molecular Medicine Reports (2020)
- IF = 5.811 Long Noncoding RNA and Circular RNA Expression Profiles of Monocyte-Derived Dendritic Cells in Autoimmune Hepatitis.. Frontiers in Pharmacology (2021)
- IF = 4.174 Long noncoding RNA MIR3142HG accelerates lipopolysaccharide-induced acute lung injury via miR-95-5p/JAK2 axis. Human Cell (2022)
- IF = 2.335 MicroRNA 27b-3p Modulates SYK in Pediatric Asthma Induced by Dust Mites. Frontiers in Pediatrics (2018)
- IF = 3.342 MicroRNA-122-5p regulates coagulation and inflammation through MASP1 and HO-1 genes. INFECTION GENETICS AND EVOLUTION (2022)
- IF = 5.037 MicroRNA-92a serves as a risk factor in sepsis-induced ARDS and regulates apoptosis and cell migration in lipopolysaccharide-induced HPMEC and A549 cell injury. LIFE SCIENCES (2020)
- IF = 4.096 MiR-128-3p inhibits vascular smooth muscle cell proliferation and migration by repressing FOXO4/MMP9 signaling pathway. MOLECULAR MEDICINE (2020)
- IF = 4.565 miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression. CELL CYCLE (2015)
- IF = 6.684 MiR-146a-5p Mimic Inhibits NLRP3 Inflammasome Downstream Inflammatory Factors and CLIC4 in Neonatal Necrotizing Enterocolitis. Frontiers in Cell and Developmental Biology (2021)
- IF = 3.024 MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.. European Review for Medical and Pharmacological Sciences (2020)
- IF = 3.212 Modulating macrophage polarization on titanium implant surface by poly(dopamine)-assisted immobilization of IL4. Clinical Implant Dentistry and Related Research (2019)
- IF = 4.966 Mycobacterial PPE13 activates inflammasome by interacting with the NATCH and LRR domains of NLRP3. FASEB JOURNAL (2020)
- IF = 2.298 Myeloid-derived suppressor cell cytokine secretion as prognostic factor in myelodysplastic syndromes:. Innate Immunity (2020)
- IF = 7.419 Nanobody-based CAR T cells targeting intracellular tumor antigens. BIOMEDICINE & PHARMACOTHERAPY (2022)
- IF = 6.51 Neutrophil membrane-coated therapeutic liposomes for targeted treatment in acute lung injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)
- IF = 4.932 NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. INTERNATIONAL IMMUNOPHARMACOLOGY (2021)
- IF = 3.909 Nucleotide-binding oligomerization domain (NOD) plays an important role in neonatal infection. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)
- IF = 6.085 Oncolytic Vaccinia Virus Carrying Aphrocallistes vastus Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells. Marine Drugs (2022)
- IF = 13.751 Original research: Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma. Journal for ImmunoTherapy of Cancer (2021)
- IF = 4.078 Overexpression of early T cell differentiation-specific transcription factors transforms the terminally differentiated effector T cells into less differentiated state. CELLULAR IMMUNOLOGY (2020)
相关实验
兔肿瘤坏死因子α（TNF-α） 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定兔血清，血浆及相关液体样本中 肿瘤坏死因子 α （TNF- α ） 的 含量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 兔肿瘤坏死因子 α （ TNF- α ） 水平。用纯化的 兔肿瘤坏死因子 α （ TNF- α ） 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 肿瘤坏死因子
牛肿瘤坏死因子 α （ TNF- α ） 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定牛血清，细胞上清及相关液体样本中 肿瘤坏死因子 α （TNF- α ） 的 含量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 牛肿瘤坏死因子 α （ TNF- α ） 水平。用纯化的 牛肿瘤坏死因子 α （ TNF- α ） 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 肿瘤坏死因子
猪肿瘤坏死因子 α （ TNF- α ） 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定猪血清，血浆及相关液体样本中 肿瘤坏死因子 α （TNF- α ） 量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 猪肿瘤坏死因子 α （ TNF- α ） 水平。用纯化的 猪肿瘤坏死因子 α （ TNF- α ） 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入
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研选
Human TNF-α High Sensitivity ELISA Kit（人肿瘤坏死因子α高敏 ELISA 试剂盒）
￥1600 - 2650
