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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
180
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
d-myc
- 抗体名：
d-myc蛋白抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul/200ul
| 规格： | 100ul | 产品价格： | ¥1580.0 |
|---|---|---|---|
| 规格： | 200ul | 产品价格： | ¥2480.0 |
英文名称 : d-myc
中文名称 : d-myc蛋白抗体
别 名 : dMyc1; MYC_DROME; Myc protein; d-Myc1; d-myc.
研究领域 : 细胞生物 免疫学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Firefly, fruit fly
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 79kDa
细胞定位 : 细胞核
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from fruit fly d-myc:121-220/717
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : Drosophila melanogaster is a proven and effective model for studying developmental and cellular processes common to higher eukaryotes. Approximately 13,600 genes have been elucidated from more than 120 megabases of euchromatin, and they are organized among the chromosomes 2, 3, 4, X and Y, with the Y chromosome being predominately heterochromatic (1). Drosophila genes can be categorized based on the type of protein they encode and are represented by six major classifications, which include intracellular signaling proteins, transmembrane proteins, RNA binding proteins, secreted factors, transcription regulators (basic helix-loop-helix, homeodomain containing, zinc finger containing, and chromatin associated) or other functional proteins (2). Many of the proteins in Drosophila are structurally and functionally similar across species, as are the pathways involved in transducing intracellular signaling. Among these proteins, myc (d-myc, dmyc1) is a transcription factor that links patterning signals to cell division by regulating events coordinating cellular growth and metabolism (3-7).
Function:
Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Inhibits the demethylase activity of Lid.
Subunit:
Heterodimer with another bHLH proteins. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with Max. Interacts with lid. Part of a complex containing lid, dm and ash2. Component of a complex with pont and rept.
Subcellular Location:
Nucleus.
Tissue Specificity:
Low levels detected throughout embryo before cellular blastoderm formation, particularly concentrated in pole plasm. Zygotic expression detected during cellular blastoderm stage in endodermal anlagen of anterior and posterior midgut at both poles. After gastrulation, expression detected in invaginating ventral furrow of mesoderm. Continued expression in anterior and posterior midgut and mesoderm during germband extension. During late germ-band retraction, expression remains detectable in fusing midgut and presumed developing somatic musculature.
Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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文献和实验3 篇 Nature 连发，解决世纪难题，周期蛋白的毁灭调控蕴含癌症患者的新生
在 cyclin D 上，被泛素化标记的 cyclin D 将会被蛋白酶体降解。此外研究还发现，AMBRA1 缺失会导致 cyclin D 和 MYC 蛋白水平升高。cyclin D 与 CDK4/6 结合，使 RB1 蛋白磷酸化。磷酸化 RB1 释放 E2F 转录因子来驱动细胞周期进程所需基因的表达。在 AMBRA1 缺失的细胞中，cyclin D 也能与 CDK2 激酶形成复合物，使癌细胞能够抵抗 CDK4/6 抑制剂的治疗。高水平的 cyclin D 会促进细胞增殖，从而导致 DNA 损伤、复制应激
浅析染色质免疫沉淀（ChIP）技术在 DNA 与蛋白质相互作用研究中的重要性
情况下的染色质结构，因此得出确凿的诱导或阻碍转录的证据，这对构架信号调控网络至关重要。同时，通过此工具也可以区分转录调控的直接作用和非直接作用 [21] ，从而使研究者对转录调控过程有更精确而深刻的认识。 ChIP 试验的结果示例 基于上述的技术优势，ChIP 首先被用来研究分子层面上的调控机制，区别于其他研究转录调控相关性的实验手段。这类分子机制研究多数是关注于 DNA 结合位点是否为启动子区或其他转录调控位点。例如，癌基因 myc 上游调控机制的研究非常之多，然而大多停留于假说阶段。Sotelo
Cell：「来骗来偷袭」剪接体靶向疗法「诱骗」机体，激活抗病毒免疫，让肿瘤自杀
传导以往研究表明，MYC 诱导的三阴性乳腺癌（triple-negative breast cancer，TNBC）对剪接体的基因扰动（genetic perturbation）很敏感，然而对剪接体抑制产生应答的途径仍然未知。基于此，作者首先对两个 MYC 诱导的 TNBC 细胞系 SUM159 和 LM2 的转录变化进行了表征，然后用小分子剪接体调节剂 SD6 进行处理。基因富集分析发现免疫信号通路（干扰素 α 和 β 信号通路）是正向富集最显著的途径，另外干扰素刺激基因 (如 OAS1、MX1
