产品货号:jlcR20053 英文名称 :C8orf80 中文名称 : 8号染色体开放阅读框80抗体 别 名 :C8orf80; GTPase SLIP-GC; SLIP_HUMAN; Speckled-like pattern in the germinal center. 研究领域 :细胞生物 信号转导 抗体来源 :Rabbit 克隆类型 :Polyclonal 交叉反应 : Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 产品应用 :ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 :91kDa 细胞定位 :细胞核 性 状 :Lyophilized or Liquid 浓 度 :1mg/ml 免 疫 原 :KLH conjugated synthetic peptide derived from human C8orf80:601-700/796 亚 型 :IgG 纯化方法 :affinity purified by Protein A 储 存 液 :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 :Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed :PubMed 产品介绍 :Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome. The C8orf80 gene product has been provisionally designated C8orf80 pending further characterization.
Function: Plays a role as replication-related GTPase protein in germinal center B-cell.
Subcellular Location: Nucleus.
Tissue Specificity: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell.
SWISS: Q68CJ6
Gene ID: 389643
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.