- ￥575 - 5213
- MedChemExpress(MCE)
- 美国
- HY-108359
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
9-Nitropaullone; NSC 705701
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
237430-03-4
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥575.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1363.0 |
| 规格： | 10 mg | 产品价格： | ￥2163.0 |
| 规格： | 25 mg | 产品价格： | ￥3713.0 |
| 规格： | 50 mg | 产品价格： | ￥5213.0 |
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Alsterpaullone
CAS No. : 237430-03-4
MCE 国际站：Alsterpaullone
产品活性：Alsterpaullone (9-Nitropaullone) 是一种高效的 CDK 抑制剂，作用于 CDK1/cyclin B、CDK2/cyclin A、CDK2/cyclin E 和 CDK5/p35 的 IC50 值分别为 35 nM、15 nM、200 nM 和 40 nM。Alsterpaullone 是 ATP 竞争性的 GSK-3alpha/GSK-3beta 抑制剂，且作用的 IC50 值都为 4 nM。Alsterpaullone 具有抗肿瘤活性，有用于神经退行性和增生性疾病研究的潜力。Alsterpaullon 诱导白血病细胞凋亡 (apoptosis)。
研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | PI3K/Akt/mTOR | Apoptosis
In Vitro: Alsterpaullone (0.3, 1, 3 μM; 8 hours) induces apoptosis in leukemia cell line.
Alsterpaullone (5, 10, 15, 20, 25, 30 μM; 48 and 72 hours) inhibits the growth of HeLa cells in dose-and time-dependent manner. Treatment with Alsterpaullone causes a time-dependent inhibition of cell growth too.
Alsterpaullone (20 μM) induces cell death depending on caspase activity.
In Vivo: Alsterpaullone (30 mg/kg, s.c., daily for 2 weeks) reduces tumor growth and increases survival in medulloblastoma xenografts.
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