- ￥363 - 5750
- MedChemExpress(MCE)
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- HY-N0551
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
524-12-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥553.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥363.0 |
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1280.0 |
| 规格： | 25 mg | 产品价格： | ￥2550.0 |
| 规格： | 50 mg | 产品价格： | ￥3950.0 |
| 规格： | 100 mg | 产品价格： | ￥5750.0 |
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Wedelolactone
CAS No. : 524-12-9
MCE 国际站：Wedelolactone
产品活性：Wedelolactone 通过直接抑制 IKK 复合物抑制 lps 诱导的 caspase-11 表达。Wedelolactone 抑制 5-Lox，其 IC50 值为 2.5 μM。Wedelolactone 通过下调 PKCε 诱导的 caspase 依赖的前列腺癌细胞凋亡，而不抑制 Akt。Wedelolactone 可从鳢肠中提取，可用于癌症的研究。
研究领域：Apoptosis | Metabolic Enzyme/Protease
作用靶点：Caspase | Lipoxygenase | Apoptosis
In Vitro: Wedelolactone (0-5 μg/mL; 0-21 d) enhances bone marrow mesenchymal stem cells (BMSC) differentiation towards osteoblasts.
Wedelolactone (0-6 μg/mL; 0-9 d) inhibits GSK3β activity and increases β-catenin and runx2 nuclear accumulation in BMSC, and inhibits the effect of RANKL.
Wedelolactone (0-5 μg/ml; 60 min) inhibits GSK3β activity and proves GSK3β is the target of wedelolactone.
Wedelolactone (0-5 μg/ml; 6 d) inhibits c-src, c-fos and cathepsin k expression level.
In Vivo: Wedelolactone (10 mg/kg; i.p. every 2 days for 4 weeks) decreases bone volumn and trabecular number at the femur after ovarietomy, and prevents the VOX-induced bone loss.
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