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NDNA3
MCE 国际站:NDNA3
产品活性:NDNA3 (compound 14) 是一种 Hsp90α 选择性抑制剂 (IC50: 0.51 μM)。NDNA3 是永久带电类似物,具有低膜渗透性,对 Ovcar-8 (IC50: 12.66 μM) 和 MCF-10A (IC50: 11.72 μM) 细胞毒性较低。NDNA3 可避免 hERG 通道成熟被破坏,不产生热休克反应或导致 Hsp90α 依赖性客户蛋白的降解。
研究领域:Cell Cycle/DNA Damage | Membrane Transporter/Ion Channel | Metabolic Enzyme/Protease
作用靶点:HSP | Potassium Channel
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文献和实验with modest levels of genomic information. For the past two decades, most population-level studies have lacked nuclear DNA (nDNA) sequence data due to the complications and cost of amplifying and sequencing diploid loci. However, pyrosequencing of emulsion PCR
Interpretation Guidelines of mtDNA Control Region Sequence Electropherograms in Forensic Genetics
Forensic mitochondrial DNA (mtDNA) analysis is a complementary technique to forensic nuclear DNA (nDNA) and trace evidence analysis. Its use has been accepted by the vast majority of courts of law around the world. However for the forensic
Analysis of Human Mitochondrial DNA Mutations
by the nuclear DNA (nDNA), that are synthesized in the cytoplasm and are transported into the mitochondrion ( 2 ). Approximately 1,000 mitochondrial polypeptides are encoded in nDNA . Complex II (succinate dehydrogenase-CoQ
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