重组人NRG1-β1(177-241a.a.)

特别提示：包括重组人NRG1-β1(177-241a.a.)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人NRG1-β1(177-241a.a.)
英文名称：Recombinant Human Neuregulin 1-beta1 EGF-like domain, 177-241a.a.
产品货号：GS4671
产品规格：10μg

分子量：Approximately 7.5kDa,a single non-glycosylated polypeptide chain containing 65 amino acids.
储存条件：冷冻（-20℃）

概述

Neuregulin 1 belongs to a family of structurally related polypeptide growth factors and is produced in numerous isoforms by alternative splicing,which allows it to perform a wide variety of functions.These isoforms include heregulins(HRGs),glial growth factors(GGFs)and sensory and motor neuron-derived factor(SMDF).They all have the Ig and EGF-like domain,and can bind to ErbB3 and ErbB4 receptor tyrosin kinases.This binding induces ErbB3 and ErbB4 heterodimerization with ErbB2,stimulating intrinsic kinase activity,which leads to tyrosine phosphorylation.NRG1 isoforms have functions of inducing the growth and differentiation of epithelial,neuronal,glial,and other types of cells.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 0.5ng/ml,corresponding to a specific activity of ＞ 2.0×106 IU/mg.
成分	Lyophilized from a 0.2μmfiltered solution in 1×PBS,pH 7.4,with 5%trehalose.
内毒素	Less than 0.1 EU/μg of rHuNRG1-β1,177-241a.a.as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE

我公司销售的重组人NRG1-β1(177-241a.a.)，Recombinant Human Neuregulin 1-beta1 EGF-like domain, 177-241a.a.，rh177-241a.a.，重组人NRG1-β1，r177-241a.a.，rhNRG1-β1，重组Neuregulin 1-beta1 EGF-like domain, 177-241a.a.，重组人Neuregulin 1-beta1 EGF-like domain, 177-241a.a.，rNRG1-β1，重组NRG1-β1，重组177-241a.a.，NRG1-β1, 177-241a.a., Human，重组人177-241a.a.质量上佳，价格普惠，欢迎广大新老客户踊跃订购。