重组人IL-36β(157a.a.)优惠促销

特别提示：包括重组人IL-36β(157a.a.)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人IL-36β(157a.a.)
英文名称：Recombinant Human Interleukin-36 beta, 157a.a.
产品货号：GS4658
产品规格：2μg

分子量：Approximately 17.7kDa,a single non-glycosylated polypeptide chain containing 157 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36 beta is reported to be expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin.Furthermore,it can stimulate production of interleukin-6 and interleukin-8 in synovial fibroblasts,articular chondrocytes and mature adipocytes.Two alternatively spliced transcript variants encode distinct(164 or 157 residues)protein isoforms that differ in their C-terminal 70 amino acid residues have been reported and IL-36β isoform 2 is synthesized as a 157 a.a.protein.Specifically,human IL-36β shares low sequence identity with IL-1β,IL-36RA,IL-36α and IL-36γ.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The specific activity is determined by its binding ability in a functional ELISA.Immobilized rHuIL-36β at 1μg/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 μg/mL.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuIL-36β,157a.a.as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSV SYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE

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