重组小鼠FGF-21北京厂家

特别提示：包括重组小鼠FGF-21在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠FGF-21
英文名称：Recombinant Murine Fibroblast Growth Factor-21
产品货号：GS4568
产品规格：5μg

分子量：Approximately 19.9kDa,a single non-glycosylated polypeptide chain containing 182 amino acids.
储存条件：冷冻（-20℃）

概述

Fibroblast growth factor-21(FGF-21)belongs to the large FGF family and it is specifically induced by HMGCS2 activity.In mice,brown adipose tissue becomes a source of systemic FGF21 after cold exposure.FGF-21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression(but not SLC2A4/GLUT4 expression)and the activity depends on the presence of KLB.FGF-21,in the presence of betaKlotho as a protein cofactor,signals through the FGFR 1c and 4 receptors.Recombinant murine FGF-21 contains 182 amino acids residues and show limited binding to heparin.In addition,Murine FGF-21 respectively shows 81%and 92%a.a.identity to human and rat FGF-21,and it show activity on human and rat cells.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5μg/ml,corresponding to a specific activity of>2.0×103 IU/mg in the presence of 5μg/ml of rMuKlotho-β and 10 μg/ml of heparin.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 3×PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rMuFGF-21 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	AYPIPDSSPL LQFGGQVRQR YLYTDDDQDT EAHLEIREDG TVVGAAHRSP ESLLELKALK PGVIQILGVK ASRFLCQQPD GALYGSPHFD PEACSFRELL LEDGYNVYQS EAHGLPLRLP QKDSPNQDAT SWGPVRFLPM PGLLHEPQDQ AGFLPPEPPD VGSSDPLSMV EPLQGRSPSY AS

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