- ￥2260
- LSM Bio
- 进口
- PAab09528
- 2025年07月07日
- ELISA,WB,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Wilms tumor 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
Wilms tumor 1
- 抗体英文名：
anti-WT1 antibody,WT1 antibody
- 抗体名：
anti-WT1 抗体,WT1 抗体
- 规格：
100μl
WT1抗体| WT1 antibody
货号 PAab09528
蛋白别名 GUD antibody, WAGR antibody, Wilms tumor 1 antibody, Wilms tumor protein antibody, WIT 2 antibody, WT1 antibody, WT33
蛋白介绍
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
产品描述
anti-WT1 antibody is a Rabbit Polyclonal antibody againstWT1..
建议稀释比例
WB:1:500-1:5000;IP:1:500-1:5000
IHC
Western blot
human kidney tissue were subjected to SDS PAGE followed by western blot with PAab09528(WT1 antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验Wilms Tumor Gene WT1 as a: Tumor Marker for Leukemic Blast Cells and Its Role in Leukemogenesis
Patients with acute leukemia have a total of approx 1012 leukemic cells at the time of diagnosis, and still have as many as 1010 leukemic cells in complete remission. The most important problem in the treatment of leukemia patients
WT1（Wilms’ tumor gene,WT1）定位于11p13，是最早发现与Wilms’肿瘤发生、发展有关的基因。 WT1主要在胚胎发生过程中表达，对泌尿生殖系统的发育起重要作用，在成人，WT1仅在肾脏、卵巢、子宫内膜、睾丸、脾脏、乳腺及正常造血祖细胞微量表达 [1]。 研究发现几乎所有的白血病原始细胞（无论系别）都持续过表达WT1，与其在极少数生理性造血干细胞（CD34 + ）中短暂低表达形成鲜明对比，定性和半定
WT-1 Overexpression in Acute Myeloid Leukemia and Myelodysplastic Syndromes
of this gene in the hematopoietic system is still quite completely obscure, it represents a reliable marker for the detection of the presence of leukemic cells. WT1 quantitative assessment may therefore represent a useful tool for the diagnosis and follow
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