TRIM21| TRIM21 antibody

TRIM21抗体| TRIM21 antibody

货号   PAab08972

蛋白别名   52 kDa Ro protein antibody, RING finger protein 81 antibody, RNF81 antibody, Ro(SS A) antibody, RO52 antibody, SS A antibody, SSA antibody, SSA1 antibody, TRIM21 antibody, tripartite motif containing 21

蛋白介绍

E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ('Thr- 187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).

产品描述

anti-TRIM21 antibody is a Rabbit Polyclonal antibody againstTRIM21..

建议稀释比例

WB:1:200-1:2000;IP:1:200-1:2000;IHC:1:20-1:200;IF:1:50-1:500

IHC

Immunohistochemistry of paraffin-embedded human lung cancer using PAab08972(TRIM21 antibody) at dilution of 1:50

Western blot

A549 cells were subjected to SDS PAGE followed by western blot with PAab08972(TRIM21 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">