- ￥2262
- LSM Bio
- 进口
- PAab08295
- 2025年07月18日
- ELISA,WB,IHC,FC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
signal transducer and activator of transcription 1, 91kDa
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,FC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
signal transducer and activator of transcription 1, 91kDa
- 抗体英文名：
anti-STAT1 antibody,STAT1 antibody
- 抗体名：
anti-STAT1 抗体,STAT1 抗体
- 规格：
100μg
STAT1抗体| STAT1 antibody
货号 PAab08295
蛋白别名
蛋白介绍
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
产品描述
anti-STAT1 antibody is a Rabbit Polyclonal antibody againstSTAT1..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using PAab08295( STAT1 Antibody) at dilution of 1:50
Western blot
PC-3 cells were subjected to SDS PAGE followed by western blot with PAab08295(STAT1 antibody) at dilution of 1:600(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验fengbozhang 各位大侠：最近投了一个paper，是关于一个细胞因子激活STAT1通路，抑制ERK1/2通路而抑制肿瘤细胞生长的。 老外的回修意见中，要求我做一个简单的小示意图，来说明作用信号传导通路。本人检索众多文献，发现无论STAT1还是ERK1/2，都很复杂，设计到很多的分子、染色体等，这个图该怎么简单说明一下呢？本人是搞临床的，弄这个东西实在很挠头啊！***高招！ kern6549 审稿人的意思应该
Assessing Sequence-Specific DNA Binding and Transcriptional Activity of STAT1 Transcription Factor
and carrier-independent transport pathways, and it was previously shown that STAT1 exits the nucleus only after its prior enzymatic dephosphorylation by nuclear phosphatases. The identification of different transport pathways for unphosphorylated and tyrosine
「七分饱」抗衰老又添科学证据！研究揭示限制饮食可改善由衰老引起的炎症反应
，而短期和长期 DR 则可显著下调其至年轻时水平或是更低的水平。 Stat1 是干扰素信号转导的重要组成部分，它介导多种细胞反应通路，包括响应不同的炎症细胞因子和生长因子的刺激。在衰老过程中，Stat1 在血液、肾脏、大脑、肌肉和肺中显著上调。有意思的是，在 LTDR 和 STDR 的干预后，肝脏、血液、肾脏和肺中的 Stat1 均出现下调。接着，他们在蛋白质水平上也验证了这一结论。 图片来源：Cell Reports 最后，为了再次证实上述基于转录组数据发现的关键转录因子（Irf
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