- ￥2262
- LSM Bio
- 进口
- PAab07993
- 2025年07月12日
- ELISA,WB,IHC,IF,IP
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
SMAD family member 2
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC,IF,IP
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
SMAD family member 2
- 抗体英文名：
anti-SMAD2 antibody,SMAD2 antibody
- 抗体名：
anti-SMAD2 抗体,SMAD2 抗体
- 规格：
100μg
SMAD2抗体| SMAD2 antibody
货号 PAab07993
蛋白别名 MADH2 antibody, MADR2 antibody,hMAD 2 antibody, hSMAD2 antibody, JV18 antibody, JV18 1 antibody, MAD homolog 2 antibody, Mad related protein 2 antibody, Mothers against DPP homolog 2 antibody, SMAD 2 antibody, SMAD family member 2 antibody, SMAD2
蛋白介绍
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
产品描述
anti-SMAD2 antibody is a Rabbit Polyclonal antibody againstSMAD2..
建议稀释比例
WB : 1:500-1:5000 IP : 1:500-1:5000 IHC : 1:50-1:500 IF : 1:10-1:100
IHC
Immunohistochemistry of paraffin-embedded human endometrial cancer tissue slide using PAab07993( SMAD2 Antibody) at dilution of 1:50
Western blot
HeLa cells were subjected to SDS PAGE followed by western blot with PAab07993(SMAD2 antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验Molecular Detection of Smad2/Smad4 Alterations in Colorectal Tumors
The signaling pathways mediated by the transforming growth factor-β (TGF-β) family of factors are implicated in a wide array of biological processes including cell differentiation and proliferation, determination of cell fate during embryogenesis
【求助】请问激活SMAD通路，samd表达上升还是其磷酸化？
hhyy601 我是细胞生物的外行，我现在请教各问题，通过SMAD信号通路，是使samd2/3磷酸化还是使samd2/3表达上升？ MIRNA下降是使samd2/3磷酸化还是表达上升，表达上升激活了这个通路吗？谢谢 zfv2007 1. smad2/3是转录因子，受到上游通路激活后发生磷酸化，然后入核调控相应靶基因的转录，所以激活应该是smad2/3的磷酸化增加。 2.在其他条件不变的情况下，smad2/3表达
secondary antibody review -- data from 99 publications
cytometry used as a control to detect cell responses targeted antigen 7 Alexa Fluor 488 7 Cy3 8 goat IgG Alexa Fluor 488 1:2000 detect antibody binding in human embryonic kidney 293T cells Invitrogen 9 donkey
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