- ￥2262
- LSM Bio
- 进口
- PAab07314
- 2025年07月11日
- ELISA,WB
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
receptor-interacting serine-threonine kinase 2
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
P67936
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
receptor-interacting serine-threonine kinase 2
- 抗体英文名：
anti-RIPK2 antibody,RIPK2 antibody
- 抗体名：
anti-RIPK2 抗体,RIPK2 抗体
- 规格：
100μg
RIPK2抗体| RIPK2 antibody
货号 PAab07314
蛋白别名 CARDIAK antibody, RICK antibody, RIP2
蛋白介绍
Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
产品描述
anti-RIPK2 antibody is a Rabbit Polyclonal antibody againstRIPK2..
建议稀释比例
IHC
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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