Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788).
产品描述
anti-RBPJ antibody is a Rabbit Polyclonal antibody againstRBPJ..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human pancreas cancer using PAab07195(RBPJ antibody) at dilution of 1:100
Western blot
mouse kidney tissue were subjected to SDS PAGE followed by western blot with PAab07195(RBPJ antibody) at dilution of 1:1000(本抗体仅供体外科研用途,不可用于临床诊断!)