- ￥2262
- LSM Bio
- 进口
- PAab06227
- 2025年07月13日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
proprotein convertase subtilisin/kexin type 9
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9WVH4
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
proprotein convertase subtilisin/kexin type 9
- 抗体英文名：
anti-PCSK9 antibody,PCSK9 antibody
- 抗体名：
anti-PCSK9 抗体,PCSK9 抗体
- 规格：
100μl
PCSK9抗体| PCSK9 antibody
货号 PAab06227
蛋白别名 NARC1
蛋白介绍
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non- acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)- mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
产品描述
anti-PCSK9 antibody is a Rabbit Polyclonal antibody againstPCSK9..
建议稀释比例
IHC
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using PAab06227( PCSK9 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Western blot
COLO 320 cells were subjected to SDS PAGE followed by western blot with PAab06227(PCSK9 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) <"">
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文献和实验Analyses of PCSK9 Post-translational Modifications Using Time-of-Flight Mass Spectrometry
successfully for protein/peptide profiling in disease states and for the detection of protein/peptide biomarkers (1–4). In this chapter, the secreted proprotein convertase subtilisin/kexin 9 (PCSK9), which we study in our lab, is used to demonstrate coupling
粥样硬化型心血管疾病（Atherosclerotic cardiovascular disease，CVD)是当前人类面临的主要致死性疾病之一，也是当前心血管疾病研究热点，动物实验是研究和探索治疗心血管疾病途径必不可少的环节。 常见动脉粥样硬化动物模型包括Apoe敲除小鼠、Ldlr敲除小鼠、在其基础上调控其他基因的品系以及其他基因调控方式调控相关基因的动物模型（表1）。 表1.不同动脉粥样硬化小鼠对比 Pcsk9D377Y在动脉粥样硬化模型小鼠中的应用 转基因
喝咖啡有益健康又添新证据！近 45 万人研究表明，每天 2~3 杯咖啡，可降低死亡风险
大麦克马斯特大学的研究人员在 Nature Communications 杂志发表研究论文 Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance，揭示了咖啡因能够增加肝细胞内质网钙离子水平，阻断 SREBP2 的激活，进而降低 PCSK9 表达水平，增加低密度脂蛋白受体（LDLR）的表达，促进坏胆固醇（低密度脂蛋白胆固醇, LDLc）的清除。该研究结果提示了咖啡
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